Titre

Platelet count and outcome in patients with acute venous thromboembolism.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Di Micco, P.
Auteure/Auteur
Ruiz-Giménez, N.
Auteure/Auteur
Nieto, J.A.
Auteure/Auteur
Aujesky, D.
Auteure/Auteur
del Molino, F.
Auteure/Auteur
Valle, R.
Auteure/Auteur
Barrón, M.
Auteure/Auteur
Maestre, A.
Auteure/Auteur
Monreal, M.
Auteure/Auteur
Contributrices/contributeurs
Monreal, M.
Decousus, H.
Prandoni, P.
Brenner, B.
Barba, R.
Di Micco, P.
Bertoletti, L.
Schellong, S.
Tzoran, I.
Dr Abilio, R.
Bosevski, M.
Bounameaux, H.
Malý, R.
Andújar, V.
Arcelus, JI.
Arroyo, M.
Ballaz, A.
Barba, R.
Barrón, M.
Barrón-Andrés, B.
Bascuñana, J.
Bedate, P.
Benítez, JF.
Blanco- Molina, A.
Boix, L.
Bosco, J.
Bueso, T.
Casado, I.
Chaves, E.
Contra, A.
de Ancos CL.,
de Miguel, J.
del Molino, F.
del Toro, J.
Elías-Hernández, T.
Falgá, C.
Farfán, A.
Fernández-Capitán, C.
Fole, D.
Font, C.
Fuentes, MI.
Gallego, P.
García-Bragado, F.
Gavín, O.
Gómez, V.
González, J.
González-Basch, E.
González-Nieto, JA.
Grau, E.
Guil, M.
Guijarro, R.
Gutiérrez, J.
Hernández, L.
Hernández-Huerta, S.
Jara, L.
Jaras, MJ.
Jiménez, D.
Lecumberri, R.
Lobo, JL.
López-Jiménez, L.
López, L.
Lorenzo, A.
Luque, JM.
Macià, M.
Madridano, O.
Maestre, A.
Marchena, PJ.
Martín, M.
Martín-Villasclaras, JJ.
Monreal, M.
Muñoz, FJ.
Nauffal, MD.
Nieto, JA.
Núñez, MJ.
Ogea, JL.
Otero, R.
Paul, HE.
Pedrajas, JM.
Peris, ML.
Quezada, CA.
Riera-Mestre, A.
Rivas, A.
Rodríguez-Dávila, MA.
Román, P.
Rosa, V.
Ruíz, J.
Ruiz-Gamietea, A.
Ruiz-Giménez, N.
Sahuquillo, JC.
Sánchez, R.
Sánchez Muñoz-Torrero JF.,
Soler, S.
Soto, MJ.
Toda, M.
Todolí, JA.
Tolosa, C.
Trujillo, J.
Valdés, M.
Valero, B.
Valle, R.
Vela, J.
Vidal, G.
Vilar, C.
Villalobos, A.
Villalta, J.
Zorrilla, V.
Gadelha, T.
Malý, R.
Hirmerova, J.
Miklosovà, M.
Salgado, E.
Bertoletti, L.
Bura-Riviere, A.
Farge-Bancel, D.
Mahe, I.
Merah, A.
Quere, I.
Schellong, S.
Faul, J.
Braester, A.
Brenner, B.
Tzoran, I.
Zeltser, D.
Barillari, G.
Ciammaichella, M.
Di Micco, P.
Dalla Valle, F.
Duce, R.
Maida, R.
Pasca, S.
Piovella, C.
Poggio, R.
Prandoni, P.
Quintavalla, R.
Rocci, A.
Rota, L.
Schenone, A.
Tiraferri, E.
Tonello, D.
Tufano, A.
Visonà, A.
Zalunardo, B.
Cardoso, C.
Santos, M.
Saraiva, M.
Bosevski, M.
Aujeski, D.
Bounameaux, H.
Mazzolai, L.
Caprini, J.
Groupes de travail
RIETE investigators
Liens vers les personnes
Liens vers les unités
ISSN
0340-6245
Statut éditorial
Publié
Date de publication
2013
Volume
110
Numéro
5
Première page
1025
Dernière page/numéro d’article
1034
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The relationship between platelet count and outcome in patients with acute venous thromboembolism (VTE) has not been consistently explored. RIETE is an ongoing registry of consecutive patients with acute VTE. We categorised patients as having very low- (<80,000/µl), low- (80,000/µl to 150,000/µl), normal- (150,000/µl to 300,000/µl), high- (300,000/µl to 450,000/µl), or very high (>450,000/µl) platelet count at baseline, and compared their three-month outcome. As of October 2012, 43,078 patients had been enrolled in RIETE: 21,319 presenting with pulmonary embolism and 21,759 with deep-vein thrombosis. In all, 502 patients (1.2%) had very low-; 5,472 (13%) low-; 28,386 (66%) normal-; 7,157 (17%) high-; and 1,561 (3.6%) very high platelet count. During the three-month study period, the recurrence rate was: 2.8%, 2.2%, 1.8%, 2.1% and 2.2%, respectively; the rate of major bleeding: 5.8%, 2.6%, 1.7%, 2.3% and 4.6%, respectively; the rate of fatal bleeding: 2.0%, 0.9%, 0.3%, 0.5% and 1.2%, respectively; and the mortality rate: 29%, 11%, 6.5%, 8.8% and 14%, respectively. On multivariate analysis, patients with very low-, low-, high- or very high platelet count had an increased risk for major bleeding (odds ratio [OR]: 2.70, 95% confidence interval [CI]: 1.85-3.95; 1.43 [1.18-1.72]; 1.23 [1.03-1.47]; and 2.13 [1.65-2.75]) and fatal bleeding (OR: 3.70 [1.92-7.16], 2.10 [1.48-2.97], 1.29 [0.88-1.90] and 2.49 [1.49-4.15]) compared with those with normal count. In conclusion, we found a U-shaped relationship between platelet count and the three-month rate of major bleeding and fatal bleeding in patients with VTE.
PID Serval
serval:BIB_15E813BB5B2E
DOI
PMID
WOS
Permalien
Date de création
2014-02-13T14:28:02.245Z
Date de création dans IRIS
2025-05-20T17:43:44Z