Titre
Ten Years of Collaborative Progress in the Quest for Orthologs.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Linard, B.
Auteure/Auteur
Ebersberger, I.
Auteure/Auteur
McGlynn, S.E.
Auteure/Auteur
Glover, N.
Auteure/Auteur
Mochizuki, T.
Auteure/Auteur
Patricio, M.
Auteure/Auteur
Lecompte, O.
Auteure/Auteur
Nevers, Y.
Auteure/Auteur
Thomas, P.D.
Auteure/Auteur
Gabaldón, T.
Auteure/Auteur
Sonnhammer, E.
Auteure/Auteur
Dessimoz, C.
Auteure/Auteur
Uchiyama, I.
Auteure/Auteur
Contributrices/contributeurs
Altenhoff, A.
Ouangraoua, A.
Vesztrocy, A.W.
Linard, B.
Dessimoz, C.
Szklarczyk, D.
Durand, D.
Emms, D.
Moi, D.
Thybert, D.
Sonnhammer, E.
Kriventseva, E.
Tang, H.
Chiba, H.
Uchiyama, I.
Ebersberger, I.
Huerta-Cepas, J.
Fernandez-Breis, J.T.
Blake, J.A.
Pryszcz, L.
Martin, M.J.
Houben, M.M.
Patricio, M.
Muffato, M.
Glover, N.
Lecompte, O.
Thomas, P.D.
Schiffer, P.
Capella-Gutierrez, S.
Cosentino, S.
McGlynn, S.E.
Kuraku, S.
Forslund, S.
Kelly, S.
Lewis, S.
Jones, T.
de Farias, T.M.
Maeda, T.
Gabaldon, T.
Iwasaki, W.
Pearson, W.
Wang, Y.
Nevers, Y.
Hara, Y.
Groupes de travail
QFO Consortium
Liens vers les personnes
Liens vers les unités
ISSN
1537-1719
Statut éditorial
Publié
Date de publication
2021-07-29
Volume
38
Numéro
8
Première page
3033
Dernière page/numéro d’article
3045
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Congress ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
Accurate determination of the evolutionary relationships between genes is a foundational challenge in biology. Homology-evolutionary relatedness-is in many cases readily determined based on sequence similarity analysis. By contrast, whether or not two genes directly descended from a common ancestor by a speciation event (orthologs) or duplication event (paralogs) is more challenging, yet provides critical information on the history of a gene. Since 2009, this task has been the focus of the Quest for Orthologs (QFO) Consortium. The sixth QFO meeting took place in Okazaki, Japan in conjunction with the 67th National Institute for Basic Biology conference. Here, we report recent advances, applications, and oncoming challenges that were discussed during the conference. Steady progress has been made toward standardization and scalability of new and existing tools. A feature of the conference was the presentation of a panel of accessible tools for phylogenetic profiling and several developments to bring orthology beyond the gene unit-from domains to networks. This meeting brought into light several challenges to come: leveraging orthology computations to get the most of the incoming avalanche of genomic data, integrating orthology from domain to biological network levels, building better gene models, and adapting orthology approaches to the broad evolutionary and genomic diversity recognized in different forms of life and viruses.
PID Serval
serval:BIB_69FF3D639B70
PMID
Open Access
Oui
Date de création
2021-04-12T12:52:21.193Z
Date de création dans IRIS
2025-05-21T04:31:23Z
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Nom
33822172_BIB_69FF3D639B70.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
350.95 KB
Format
Adobe PDF
PID Serval
serval:BIB_69FF3D639B70.P001
URN
urn:nbn:ch:serval-BIB_69FF3D639B703
Somme de contrôle
(MD5):51c415311ffa9de34b28a188451f3424