Titre
Possible synergism of physical exercise and ghrelin-agonists in patients with cachexia associated with chronic heart failure.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Invernizzi, M.
Auteure/Auteur
Carda, S.
Auteure/Auteur
Cisari, C.
Auteure/Auteur
Groupes de travail
Società Italiana per lo Studio della Sarcopenia e della Disabilità Muscolo-Scheletrica (SISDIM)
Liens vers les personnes
Liens vers les unités
ISSN
1720-8319
Statut éditorial
Publié
Date de publication
2014-08
Volume
26
Numéro
4
Première page
341
Dernière page/numéro d’article
351
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
The occurrence of cachexia of multifactorial etiology in chronic heart failure (CHF) is a common and underestimated condition that usually leads to poor outcome and low survival rates, with high direct and indirect costs for the Health Care System. Recently, a consensus definition on cachexia has been reached, leading to a growing interest by the scientific community in this condition, which characterizes the last phase of many chronic diseases (i.e., cancer, acquired immunodeficiency syndrome). The etiology of cachexia is multifactorial and the underlying pathophysiological mechanisms are essentially the following: anorexia and malnourishment; immune overactivity and systemic inflammation; and endocrine disorders (anabolic/catabolic imbalance and resistance to growth hormone). In this paper, we review the main pathophysiological mechanisms underlying CHF cachexia, focusing also on the broad spectrum of actions of ghrelin and ghrelin agonists, and their possible use in combination with physical exercise to contrast CHF cachexia.
PID Serval
serval:BIB_AF10023A3978
PMID
Date de création
2015-01-22T18:14:31.341Z
Date de création dans IRIS
2025-05-21T02:15:34Z
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Nom
BIB_AF10023A3978.P001.pdf
Version du manuscrit
published
Taille
323.29 KB
Format
Adobe PDF
PID Serval
serval:BIB_AF10023A3978.P001
URN
urn:nbn:ch:serval-BIB_AF10023A39780
Somme de contrôle
(MD5):ebdbbd639e6346b674b9c6d7fdbbba7d