Titre
Hipertensión y edema pulmonar de altura. Rol de la disfunción endotelial y de la programación fetal [Pulmonary hypertension and lung edema at high altitude. Role of endothelial dysfunction and fetal programming].
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Schwab, M.
Auteure/Auteur
Allemann, Y.
Auteure/Auteur
Rexhaj, E.
Auteure/Auteur
Rimoldi, S.F.
Auteure/Auteur
Sartori, C.
Auteure/Auteur
Scherrer, U.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0025-7680
Statut éditorial
Publié
Date de publication
2012
Volume
72
Numéro
2
Première page
150
Dernière page/numéro d’article
157
Peer-reviewed
Oui
Langue
espagnol
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
High altitude constitutes an exciting natural laboratory for medical research. While initially, the aim of high-altitude research was to understand the adaptation of the organism to hypoxia and find treatments for altitude-related diseases, over the past decade or so, the scope of this research has broadened considerably. Two important observations led to the foundation for the broadening of the scientific scope of high-altitude research. First, high-altitude pulmonary edema (HAPE) represents a unique model which allows studying fundamental mechanisms of pulmonary hypertension and lung edema in humans. Secondly, the ambient hypoxia associated with high-altitude exposure facilitates the detection of pulmonary and systemic vascular dysfunction at an early stage. Here, we review studies that, by capitalizing on these observations, have led to the description of novel mechanisms underpinning lung edema and pulmonary hypertension and to the first direct demonstration of fetal programming of vascular dysfunction in humans.
PID Serval
serval:BIB_E1D4D01048FB
PMID
Date de création
2013-01-22T14:26:07.990Z
Date de création dans IRIS
2025-05-21T05:15:11Z