Titre
Endothelin B receptor, a new target in cancer immune therapy.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Kandalaft, L.E.
Auteure/Auteur
Facciabene, A.
Auteure/Auteur
Buckanovich, R.J.
Auteure/Auteur
Coukos, G.
Auteure/Auteur
Liens vers les personnes
ISSN
1078-0432
Statut éditorial
Publié
Date de publication
2009
Volume
15
Numéro
14
Première page
4521
Dernière page/numéro d’article
4528
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
The endothelins and their G protein-coupled receptors A and B have been implicated in numerous diseases and have recently emerged as pivotal players in a variety of malignancies. Tumors overexpress the endothelin 1 (ET-1) ligand and the endothelin-A-receptor (ET(A)R). Their interaction induces tumor growth and metastasis by promoting tumor cell survival and proliferation, angiogenesis, and tissue remodeling. On the basis of results from xenograft models, drug development efforts have focused on antagonizing the autocrine-paracrine effects mediated by ET-1/ET(A)R. In this review, we discuss a novel role of the endothelin-B-receptor (ET(B)R) in tumorigenesis and the effect of its blockade during cancer immune therapy. We highlight key characteristics of the B receptor such as its specific overexpression in the tumor compartment; and specifically, in the tumor endothelium, where its activation by ET-1 suppresses T-cell adhesion and homing to tumors. We also review our recent findings on the effects of ET(B)R-specific blockade in increasing T-cell homing to tumors and enhancing the efficacy of otherwise ineffective immunotherapy.
Sujets
PID Serval
serval:BIB_B040F90D1DBC
PMID
Open Access
Oui
Date de création
2014-10-14T10:42:43.331Z
Date de création dans IRIS
2025-05-20T22:10:24Z
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19567593AM .pdf
Version du manuscrit
postprint
Taille
1022.74 KB
Format
Adobe PDF
PID Serval
serval:BIB_B040F90D1DBC.P003
Somme de contrôle
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