Titre
Search for antifungal, molluscicidal and larvicidal compounds from African medicinal plants
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Marston, A.
Auteure/Auteur
Maillard, M.
Auteure/Auteur
Hostettmann, K.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0378-8741
Statut éditorial
Publié
Date de publication
1993-03
Volume
38
Numéro
2-3
Première page
215
Dernière page/numéro d’article
23
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Mar
Research Support, Non-U.S. Gov't
Review --- Old month value: Mar
Résumé
African medicinal plants provide a rich source of biologically-active natural products. By the use of simple bioassays in conjunction with an approach involving bioactivity guided fractionation, it is possible to isolate novel compounds with interesting properties. Several hundred plant extracts have been submitted to different screens, including bioautography on TLC plates with the fungi Cladosporium cucumerinum and Candida albicans. Among the other test systems are a bioassay for molluscicidal activity with the schistosomiasis-transmitting snail Biomphalaria glabrata and a benchtop assay for larvicidal activity with larvae of the mosquito Aedes aegypti, the vector of yellow fever. Using a variety of modern separation techniques, a number of compounds with activity in these bioassays have been isolated. These include prenylated xanthones, tetracyclic phenols and saponins. The role of saponins and saponin-containing plants in the control of schistosomiasis is outlined.
Sujets
PID Serval
serval:BIB_B68E92878DDC
PMID
Date de création
2008-01-25T11:59:42.954Z
Date de création dans IRIS
2025-05-20T21:14:22Z