Titre
Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Acheson, K.J.
Auteure/Auteur
Schutz, Y.
Auteure/Auteur
Bessard, T.
Auteure/Auteur
Anantharaman, K.
Auteure/Auteur
Flatt, J.P.
Auteure/Auteur
Jéquier, E.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0002-9165
Statut éditorial
Publié
Date de publication
1988
Volume
48
Numéro
2
Première page
240
Dernière page/numéro d’article
247
Langue
anglais
Résumé
The metabolic balance method was performed on three men to investigate the fate of large excesses of carbohydrate. Glycogen stores, which were first depleted by diet (3 d, 8.35 +/- 0.27 MJ [1994 +/- 65 kcal] decreasing to 5.70 +/- 1.03 MJ [1361 +/- 247 kcal], 15% protein, 75% fat, 10% carbohydrate) and exercise, were repleted during 7 d carbohydrate overfeeding (11% protein, 3% fat, and 86% carbohydrate) providing 15.25 +/- 1.10 MJ (3642 +/- 263 kcal) on the first day, increasing progressively to 20.64 +/- 1.30 MJ (4930 +/- 311 kcal) on the last day of overfeeding. Glycogen depletion was again accomplished with 2 d of carbohydrate restriction (2.52 MJ/d [602 kcal/d], 85% protein, and 15% fat). Glycogen storage capacity in man is approximately 15 g/kg body weight and can accommodate a gain of approximately 500 g before net lipid synthesis contributes to increasing body fat mass. When the glycogen stores are saturated, massive intakes of carbohydrate are disposed of by high carbohydrate-oxidation rates and substantial de novo lipid synthesis (150 g lipid/d using approximately 475 g CHO/d) without postabsorptive hyperglycemia.
PID Serval
serval:BIB_CC16E53BB20D
PMID
Date de création
2008-01-21T12:09:33.428Z
Date de création dans IRIS
2025-05-21T04:03:22Z