Titre
The Pediatric Choroidal and Ciliary Body Melanoma Study: A Survey by the European Ophthalmic Oncology Group.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Al-Jamal, R.T.
Auteure/Auteur
Cassoux, N.
Auteure/Auteur
Desjardins, L.
Auteure/Auteur
Damato, B.
Auteure/Auteur
Konstantinidis, L.
Auteure/Auteur
Coupland, S.E.
Auteure/Auteur
Heimann, H.
Auteure/Auteur
Petrovic, A.
Auteure/Auteur
Zografos, L.
Auteure/Auteur
Schalenbourg, A.
Auteure/Auteur
Velazquez-Martin, J.P.
Auteure/Auteur
Krema, H.
Auteure/Auteur
Bogdali, A.
Auteure/Auteur
Markiewicz, A.
Auteure/Auteur
Romanowska-Dixon, B.
Auteure/Auteur
Metz, C.H.
Auteure/Auteur
Biewald, E.
Auteure/Auteur
Bornfeld, N.
Auteure/Auteur
Kiratli, H.
Auteure/Auteur
Bronkhorst, I.H.
Auteure/Auteur
Jager, M.J.
Auteure/Auteur
Marinkovic, M.
Auteure/Auteur
Fili, M.
Auteure/Auteur
Seregard, S.
Auteure/Auteur
Frenkel, S.
Auteure/Auteur
Pe'er, J.
Auteure/Auteur
Salvi, S.M.
Auteure/Auteur
Rennie, I.G.
Auteure/Auteur
Rospond-Kubiak, I.
Auteure/Auteur
Kociecki, J.
Auteure/Auteur
Kiilgaard, J.F.
Auteure/Auteur
Heegaard, S.
Auteure/Auteur
Cohen, V.M.
Auteure/Auteur
Sagoo, M.S.
Auteure/Auteur
Amiryan, A.
Auteure/Auteur
Saakyan, S.
Auteure/Auteur
Eide, N.
Auteure/Auteur
Krohn, J.
Auteure/Auteur
Midena, E.
Auteure/Auteur
Parrozzani, R.
Auteure/Auteur
Grange, J.D.
Auteure/Auteur
Kilic, E.
Auteure/Auteur
Blasi, M.A.
Auteure/Auteur
Saornil, M.A.
Auteure/Auteur
Kivelä, T.T.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1549-4713
Statut éditorial
Publié
Date de publication
2016
Volume
123
Numéro
4
Première page
898
Dernière page/numéro d’article
907
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
PURPOSE: To collect comprehensive data on choroidal and ciliary body melanoma (CCBM) in children and to validate hypotheses regarding pediatric CCBM: children younger than 18 years, males, and those without ciliary body involvement (CBI) have more favorable survival prognosis than young adults 18 to 24 years of age, females, and those with CBI.
DESIGN: Retrospective, multicenter observational study.
PARTICIPANTS: Two hundred ninety-nine patients from 24 ocular oncology centers, of whom 114 were children (median age, 15.1 years; range, 2.7-17.9 years) and 185 were young adults.
METHODS: Data were entered through a secure website and were reviewed centrally. Survival was analyzed using Kaplan-Meier analysis and Cox proportional hazards regression.
MAIN OUTCOME MEASURES: Proportion of females, tumor-node-metastasis (TNM) stage, cell type, and melanoma-related mortality.
RESULTS: Cumulative frequency of having CCBM diagnosed increased steadily by 0.8% per year of age between 5 and 10 years of age and, after a 6-year transition period, by 8.8% per year from age 17 years onward. Of children and young adults, 57% and 63% were female, respectively, which exceeded the expected 51% among young adults. Cell type, known for 35% of tumors, and TNM stage (I in 22% and 21%, II in 49% and 52%, III in 30% and 28%, respectively) were comparable for children and young adults. Melanoma-related survival was 97% and 90% at 5 years and 92% and 80% at 10 years for children compared with young adults, respectively (P = 0.013). Males tended to have a more favorable survival than females among children (100% vs. 85% at 10 years; P = 0.058). Increasing TNM stage was associated with poorer survival (stages I, II, and III: 100% vs. 86% vs. 76%, respectively; P = 0.0011). By multivariate analysis, being a young adult (adjusted hazard rate [HR], 2.57), a higher TNM stage (HR, 2.88 and 8.38 for stages II and III, respectively), and female gender (HR, 2.38) independently predicted less favorable survival. Ciliary body involvement and cell type were not associated with survival.
CONCLUSIONS: This study confirms that children with CCBM have a more favorable survival than young adults 18 to 25 years of age, adjusting for TNM stage and gender. The association between gender and survival varies between age groups.
DESIGN: Retrospective, multicenter observational study.
PARTICIPANTS: Two hundred ninety-nine patients from 24 ocular oncology centers, of whom 114 were children (median age, 15.1 years; range, 2.7-17.9 years) and 185 were young adults.
METHODS: Data were entered through a secure website and were reviewed centrally. Survival was analyzed using Kaplan-Meier analysis and Cox proportional hazards regression.
MAIN OUTCOME MEASURES: Proportion of females, tumor-node-metastasis (TNM) stage, cell type, and melanoma-related mortality.
RESULTS: Cumulative frequency of having CCBM diagnosed increased steadily by 0.8% per year of age between 5 and 10 years of age and, after a 6-year transition period, by 8.8% per year from age 17 years onward. Of children and young adults, 57% and 63% were female, respectively, which exceeded the expected 51% among young adults. Cell type, known for 35% of tumors, and TNM stage (I in 22% and 21%, II in 49% and 52%, III in 30% and 28%, respectively) were comparable for children and young adults. Melanoma-related survival was 97% and 90% at 5 years and 92% and 80% at 10 years for children compared with young adults, respectively (P = 0.013). Males tended to have a more favorable survival than females among children (100% vs. 85% at 10 years; P = 0.058). Increasing TNM stage was associated with poorer survival (stages I, II, and III: 100% vs. 86% vs. 76%, respectively; P = 0.0011). By multivariate analysis, being a young adult (adjusted hazard rate [HR], 2.57), a higher TNM stage (HR, 2.88 and 8.38 for stages II and III, respectively), and female gender (HR, 2.38) independently predicted less favorable survival. Ciliary body involvement and cell type were not associated with survival.
CONCLUSIONS: This study confirms that children with CCBM have a more favorable survival than young adults 18 to 25 years of age, adjusting for TNM stage and gender. The association between gender and survival varies between age groups.
Sujets
PID Serval
serval:BIB_1B05266DD954
PMID
Date de création
2016-02-20T14:42:00.969Z
Date de création dans IRIS
2025-05-20T14:24:44Z