Titre
The morphogenetic signal of bacteriophage f1.
Type
article
Institution
Externe
Périodique
Auteur(s)
Dotto, G.P.
Auteure/Auteur
Zinder, N.D.
Auteure/Auteur
Liens vers les personnes
ISSN
0042-6822
Statut éditorial
Publié
Date de publication
1983
Volume
130
Numéro
1
Première page
252
Dernière page/numéro d’article
256
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
The genome of the single-stranded DNA phage f1 contains an intergenic region (IG), 508-nucleotides long, that does not code for any known protein. By use of a system of chimeric plasmids haboring different f1 fragments, we had previously shown that this region contains, in addition to the f1 'functional origin' of DNA replication, a signal of less than 300 nucleotides required for efficient morphogenesis to occur ('morphogenetic signal'). In the present study, we have localized this signal to within a sequence of less that 60 nucleotides of almost perfect palindromic symmetry at the genet IV/IG border. We also present data indicating that the morphogenetic signal is not necessary for the synthesis of single-stranded DNA, but is necessary only at some later step during virion maturation.
PID Serval
serval:BIB_36AFA09918F0
PMID
Date de création
2008-01-24T13:59:00.375Z
Date de création dans IRIS
2025-05-20T15:32:02Z