Titre
Interference of pollutants with PPARs: endocrine disruption meets metabolism.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Casals-Casas, C.
Auteure/Auteur
Feige, J.N.
Auteure/Auteur
Desvergne, B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1476-5497[electronic]
Statut éditorial
Publié
Date de publication
2008
Volume
32 Suppl 6
Première page
S53
Dernière page/numéro d’article
S61
Peer-reviewed
Oui
Langue
anglais
Résumé
The concept of endocrine disruption emerged over a decade ago with the observation that several natural or industrial compounds can interfere with estrogen and androgen signaling, and thereby affect both male and female reproductive functions. Since then, many endocrine-disrupting chemicals (EDCs) have been identified and the concept has been broadened to receptors regulating other aspects of endocrine pathways. In that context, interference of EDCs with receptors regulating metabolism has been proposed as a factor that could contribute to metabolic diseases such as obesity and diabetes. We review recent studies showing that several pollutants, including phthalates and organotins, interfere with PPAR (peroxisome proliferator-activated receptors) nuclear receptors and may thereby affect metabolic homeostasis. Particular emphasis is given on the mechanisms of action of these compounds. However, unlike what has been suspected, we provide evidence from mouse models suggesting that in utero exposure to the phthalate ester di-ethyl-hexyl-phthalate most likely does not predispose to obesity. Collectively, these studies define a subclass of EDCs that perturb metabolic signaling and that we propose to define as metabolic disruptors.
PID Serval
serval:BIB_550FA06D7F26
PMID
Open Access
Oui
Date de création
2009-04-06T14:56:41.373Z
Date de création dans IRIS
2025-05-20T13:48:27Z