Titre
Changes of lipoprotein(a) levels with endogenous steroid hormones.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Tessitore, E.
Auteure/Auteur
Dobretz, K.
Auteure/Auteur
Dhayat, N.A.
Auteure/Auteur
Kern, I.
Auteure/Auteur
Ponte, B.
Auteure/Auteur
Pruijm, M.
Auteure/Auteur
Ackermann, D.
Auteure/Auteur
Estoppey, S.
Auteure/Auteur
Burnier, M.
Auteure/Auteur
Martin, P.Y.
Auteure/Auteur
Vogt, B.
Auteure/Auteur
Vuilleumier, N.
Auteure/Auteur
Bochud, M.
Auteure/Auteur
Mach, F.
Auteure/Auteur
Ehret, G.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1365-2362
Statut éditorial
Publié
Date de publication
2022-02
Volume
52
Numéro
2
Première page
e13699
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
Lipoprotein(a) [Lp(a)] is an LDL-like molecule that is likely causal for cardiovascular events and Lp(a) variability has been shown to be mostly of genetic origin. Exogenous hormones (hormone replacement therapy) seem to influence Lp(a) levels, but the impact of endogenous hormone levels on Lp(a) is still unknown. The aim of the study was to assess the effect of endogenous steroid hormone metabolites on Lp(a).
Lipoprotein(a) levels were measured in 1,021 participants from the Swiss Kidney Project on Genes in Hypertension, a family-based, multicentre, population-based prospective cohort study. Endogenous levels of 28 steroid hormone precursors were measured in 24-h urine collections from 883 individuals. Of the participants with Lp(a) data, 1,011 participants had also genotypes available.
The participants had an average age of 51 years and 53% were female. Median Lp(a) levels were 62 mg/L, and the 90 <sup>th</sup> percentile was 616 mg/L. The prevalence of a Lp(a) elevation ≥700 mg/L was 3.2%. Forty-three per cent of Lp(a) variability was explained respectively by: age (2%, p < .001), LDL-C (1%, p = .001), and two SNPs (39%, p value<2⋅10 <sup>-16</sup> ). Of the 28 endogenous steroid hormones assessed, androstenetriol, androsterone, 16α-OH-DHEA and estriol were nominatively associated with serum Lp(a) levels in univariable analyses and explained 0.4%-1% of Lp(a) variability, but none of them reached significance in multivariable models.
In this contemporary population-based study, the prevalence of a Lp(a) elevation ≥700 mg/L was 3.2%. The effect of endogenous steroid hormone levels of Lp(a) variability was small at best, suggesting a negligible impact on the wide range of Lp(a) variability.
Lipoprotein(a) levels were measured in 1,021 participants from the Swiss Kidney Project on Genes in Hypertension, a family-based, multicentre, population-based prospective cohort study. Endogenous levels of 28 steroid hormone precursors were measured in 24-h urine collections from 883 individuals. Of the participants with Lp(a) data, 1,011 participants had also genotypes available.
The participants had an average age of 51 years and 53% were female. Median Lp(a) levels were 62 mg/L, and the 90 <sup>th</sup> percentile was 616 mg/L. The prevalence of a Lp(a) elevation ≥700 mg/L was 3.2%. Forty-three per cent of Lp(a) variability was explained respectively by: age (2%, p < .001), LDL-C (1%, p = .001), and two SNPs (39%, p value<2⋅10 <sup>-16</sup> ). Of the 28 endogenous steroid hormones assessed, androstenetriol, androsterone, 16α-OH-DHEA and estriol were nominatively associated with serum Lp(a) levels in univariable analyses and explained 0.4%-1% of Lp(a) variability, but none of them reached significance in multivariable models.
In this contemporary population-based study, the prevalence of a Lp(a) elevation ≥700 mg/L was 3.2%. The effect of endogenous steroid hormone levels of Lp(a) variability was small at best, suggesting a negligible impact on the wide range of Lp(a) variability.
PID Serval
serval:BIB_5156A7619A31
PMID
Open Access
Oui
Date de création
2021-11-03T12:32:09.126Z
Date de création dans IRIS
2025-05-20T19:26:50Z
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Nom
34695230_BIB_5156A7619A31.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
348.85 KB
Format
Adobe PDF
PID Serval
serval:BIB_5156A7619A31.P001
URN
urn:nbn:ch:serval-BIB_5156A7619A313
Somme de contrôle
(MD5):03ddc8e9714105cdc8965355832bac1e