Titre
Intravenous infusion of a medium-chain triglyceride-enriched lipid emulsion
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Weissman, C.
Auteure/Auteur
Chiolero, R.
Auteure/Auteur
Askanazi, J.
Auteure/Auteur
Gil, K. M.
Auteure/Auteur
Elwyn, D.
Auteure/Auteur
Kinney, J. M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0090-3493
Statut éditorial
Publié
Date de publication
1988-12
Volume
16
Numéro
12
Première page
1183
Dernière page/numéro d’article
90
Notes
Journal Article --- Old month value: Dec
Résumé
There has been much interest in the parenteral use of medium-chain triglycerides (MCT) as a noncarbohydrate energy source. This study examines the effects of infusion iv into postabsorptive normal subjects with three doses (0.5, 1.0, 1.5 g/kg.15 h) of an emulsion containing 56% MCT and 44% long-chain triglyceride (LCT) and comparing its metabolic effect with infusions of normal saline (NS) and an emulsion containing LCT alone. There were significant increases in serum beta-hydroxybutyrate and acetoacetate 5 and 15 h after the start of the MCT-LCT infusions. Increases were seen only after 15 h of NS, while none was observed during LCT alone. Triglycerides were increased in a dose-related fashion with MCT-LCT and were increased even further with LCT alone. Glycerol increased in a dose-related fashion both during the MCT-LCT and LCT infusion beginning immediately (0.5 h) after the start of the infusion. With NS infusion, glycerol increased significantly only after 15 h of infusion. The MCT-LCT mixture and the highest LCT dose resulted in a significant (12%) increase in oxygen consumption after 5 h of infusion. There was no difference in oral glucose tolerance between the various infusions. Infusion of MCT results in significant ketogenesis and more study is needed to determine its clinical utility.
Sujets
PID Serval
serval:BIB_1A6285D054B9
PMID
Date de création
2008-01-24T15:52:53.501Z
Date de création dans IRIS
2025-05-20T20:32:02Z