Titre
Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Pacher, P.
Auteure/Auteur
Mabley, J.G.
Auteure/Auteur
Liaudet, L.
Auteure/Auteur
Evgenov, O.V.
Auteure/Auteur
Marton, A.
Auteure/Auteur
Haskó, G.
Auteure/Auteur
Kollai, M.
Auteure/Auteur
Szabó, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0363-6135
Statut éditorial
Publié
Date de publication
2004-11
Volume
287
Numéro
5
Première page
H2132
Dernière page/numéro d’article
2137
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Aging is associated with profound changes in the structure and function of the heart. A fundamental understanding of these processes, using relevant animal models, is required for effective prevention and treatment of cardiovascular disease in the elderly. Here, we studied cardiac performance in 4- to 5-mo-old (young) and 24- to 26-mo-old (old) Fischer 344 male rats using the Millar pressure-volume (P-V) conductance catheter system. We evaluated systolic and diastolic function in vivo at different preloads, including preload recruitable stroke work (PRSW), maximal slope of the systolic pressure increment (+dP/dt), and its relation to end-diastolic volume (+dP/dt-EDV) as well as the time constant of left ventricular pressure decay, as an index of relaxation. The slope of the end-diastolic P-V relation (EDPVR), an index of left ventricular stiffness, was also calculated. Aging was associated with decrease in left ventricular systolic pressure, +dP/dt, maximal slope of the diastolic pressure decrement, +dP/dt-EDV, PRSW, ejection fraction, stroke volume, cardiac and stroke work indexes, and efficiency. In contrast, total peripheral resistance, left ventricular end-diastolic volume, left ventricular end-diastolic pressure, and EDPVR were greater in aging than in young animals. Taken together, these data suggest that advanced aging is characterized by decreased systolic performance accompanied by delayed relaxation and increased diastolic stiffness of the heart in male Fischer 344 rats. P-V analysis is a sensitive method to determine cardiac function in rats.
PID Serval
serval:BIB_D738B0B2AF80
PMID
Date de création
2008-01-24T16:00:58.331Z
Date de création dans IRIS
2025-05-21T00:02:56Z
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Nom
15231502_Postprint.pdf
Version du manuscrit
preprint
Taille
514.94 KB
Format
Adobe PDF
PID Serval
serval:BIB_D738B0B2AF80.P001
URN
urn:nbn:ch:serval-BIB_D738B0B2AF808
Somme de contrôle
(MD5):8a036ddde73d6e2c6d9bfe4ba2ea03bb