Titre
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Dostert, C.
Auteure/Auteur
Petrilli, V.
Auteure/Auteur
Van, B. R.
Auteure/Auteur
Steele, C.
Auteure/Auteur
Mossman, B. T.
Auteure/Auteur
Tschopp, J.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1095-9203
Statut éditorial
Publié
Date de publication
2008
Volume
320
Numéro
5876
Première page
674
Dernière page/numéro d’article
677
Peer-reviewed
Oui
Langue
anglais
Résumé
The inhalation of airborne pollutants, such as asbestos or silica, is linked to inflammation of the lung, fibrosis, and lung cancer. How the presence of pathogenic dust is recognized and how chronic inflammatory diseases are triggered are poorly understood. Here, we show that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1beta secretion. Inflammasome activation is triggered by reactive oxygen species, which are generated by a NADPH oxidase upon particle phagocytosis. (NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate.) In a model of asbestos inhalation, Nalp3-/- mice showed diminished recruitment of inflammatory cells to the lungs, paralleled by lower cytokine production. Our findings implicate the Nalp3 inflammasome in particulate matter-related pulmonary diseases and support its role as a major proinflammatory "danger" receptor
PID Serval
serval:BIB_5F86B2198DA5
PMID
Date de création
2009-01-29T21:13:33.401Z
Date de création dans IRIS
2025-05-20T20:56:39Z
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Nom
18403674_Postprint.pdf
Version du manuscrit
preprint
Taille
1.05 MB
Format
Adobe PDF
PID Serval
serval:BIB_5F86B2198DA5.P001
URN
urn:nbn:ch:serval-BIB_5F86B2198DA58
Somme de contrôle
(MD5):e8e1744d7de620bf7932b1c812d04018