Titre
Regulation of mitochondrial biogenesis.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Jornayvaz, F.R.
Auteure/Auteur
Shulman, G.I.
Auteure/Auteur
Liens vers les personnes
ISSN
1744-1358
Statut éditorial
Publié
Date de publication
2010
Volume
47
Première page
69
Dernière page/numéro d’article
84
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
Although it is well established that physical activity increases mitochondrial content in muscle, the molecular mechanisms underlying this process have only recently been elucidated. Mitochondrial dysfunction is an important component of different diseases associated with aging, such as Type 2 diabetes and Alzheimer's disease. PGC-1alpha (peroxisome-proliferator-activated receptor gamma co-activator-1alpha) is a co-transcriptional regulation factor that induces mitochondrial biogenesis by activating different transcription factors, including nuclear respiratory factor 1 and nuclear respiratory factor 2, which activate mitochondrial transcription factor A. The latter drives transcription and replication of mitochondrial DNA. PGC-1alpha itself is regulated by several different key factors involved in mitochondrial biogenesis, which will be reviewed in this chapter. Of those, AMPK (AMP-activated protein kinase) is of major importance. AMPK acts as an energy sensor of the cell and works as a key regulator of mitochondrial biogenesis. AMPK activity has been shown to decrease with age, which may contribute to decreased mitochondrial biogenesis and function with aging. Given the potentially important role of mitochondrial dysfunction in the pathogenesis of numerous diseases and in the process of aging, understanding the molecular mechanisms regulating mitochondrial biogenesis and function may provide potentially important novel therapeutic targets.
PID Serval
serval:BIB_61DB56725866
PMID
Date de création
2015-11-03T11:34:01.686Z
Date de création dans IRIS
2025-05-20T15:18:36Z