Titre
Variation in detection of ductal carcinoma in situ during screening mammography : a survey within the International Cancer Screening Network.
Type
article
Institution
Externe
Périodique
Auteur(s)
Lynge, E.
Auteure/Auteur
Ponti, A.
Auteure/Auteur
James, T.
Auteure/Auteur
Májek, O.
Auteure/Auteur
von Euler-Chelpin, M.
Auteure/Auteur
Anttila, A.
Auteure/Auteur
Fitzpatrick, P.
Auteure/Auteur
Frigerio, A.
Auteure/Auteur
Kawai, M.
Auteure/Auteur
Scharpantgen, A.
Auteure/Auteur
Broeders, M.
Auteure/Auteur
Hofvind, S.
Auteure/Auteur
Vidal, C.
Auteure/Auteur
Ederra, M.
Auteure/Auteur
Salas, D.
Auteure/Auteur
Bulliard, J.L.
Auteure/Auteur
Tomatis, M.
Auteure/Auteur
Kerlikowske, K.
Auteure/Auteur
Taplin, S.
Auteure/Auteur
Groupes de travail
ICSN DCIS Working group
Liens vers les personnes
ISSN
1879-0852
Statut éditorial
Publié
Date de publication
2014
Volume
50
Numéro
1
Première page
185
Dernière page/numéro d’article
192
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND: There is concern about detection of ductal carcinoma in situ (DCIS) in screening mammography. DCIS accounts for a substantial proportion of screen-detected lesions but its effect on breast cancer mortality is debated. The International Cancer Screening Network conducted a comparative analysis to determine variation in DCIS detection.
PATIENTS AND METHODS: Data were collected during 2004-2008 on number of screening examinations, detected breast cancers, DCIS cases and Globocan 2008 breast cancer incidence rates derived from national or regional cancer registers. We calculated screen-detection rates for breast cancers and DCIS.
RESULTS: Data were obtained from 15 screening settings in 12 countries; 7,176,050 screening examinations; 29,605 breast cancers and 5324 DCIS cases. The ratio between highest and lowest breast cancer incidence was 2.88 (95% confidence interval (CI) 2.76-3.00); 2.97 (95% CI 2.51-3.51) for detection of breast cancer; and 3.49 (95% CI 2.70-4.51) for detection of DCIS.
CONCLUSIONS: Considerable international variation was found in DCIS detection. This variation could not be fully explained by variation in incidence nor in breast cancer detection rates. It suggests the potential for wide discrepancies in management of DCIS resulting in overtreatment of indolent DCIS or undertreatment of potentially curable disease. Comprehensive cancer registration is needed to monitor DCIS detection. Efforts to understand discrepancies and standardise management may improve care.
PATIENTS AND METHODS: Data were collected during 2004-2008 on number of screening examinations, detected breast cancers, DCIS cases and Globocan 2008 breast cancer incidence rates derived from national or regional cancer registers. We calculated screen-detection rates for breast cancers and DCIS.
RESULTS: Data were obtained from 15 screening settings in 12 countries; 7,176,050 screening examinations; 29,605 breast cancers and 5324 DCIS cases. The ratio between highest and lowest breast cancer incidence was 2.88 (95% confidence interval (CI) 2.76-3.00); 2.97 (95% CI 2.51-3.51) for detection of breast cancer; and 3.49 (95% CI 2.70-4.51) for detection of DCIS.
CONCLUSIONS: Considerable international variation was found in DCIS detection. This variation could not be fully explained by variation in incidence nor in breast cancer detection rates. It suggests the potential for wide discrepancies in management of DCIS resulting in overtreatment of indolent DCIS or undertreatment of potentially curable disease. Comprehensive cancer registration is needed to monitor DCIS detection. Efforts to understand discrepancies and standardise management may improve care.
PID Serval
serval:BIB_130CBE0227E3
PMID
Open Access
Oui
Date de création
2014-02-07T17:22:31.419Z
Date de création dans IRIS
2025-05-20T19:04:54Z
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BIB_130CBE0227E3.P001.pdf
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Adobe PDF
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