Titre

Migration and horizontal gene transfer divide microbial genomes into multiple niches.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Niehus, R.
Auteure/Auteur
Mitri, S.
Auteure/Auteur
Fletcher, A.G.
Auteure/Auteur
Foster, K.R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2041-1723
Statut éditorial
Publié
Date de publication
2015
Volume
6
Première page
8924
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Horizontal gene transfer is central to microbial evolution, because it enables genetic regions to spread horizontally through diverse communities. However, how gene transfer exerts such a strong effect is not understood. Here we develop an eco-evolutionary model and show how genetic transfer, even when rare, can transform the evolution and ecology of microbes. We recapitulate existing models, which suggest that asexual reproduction will overpower horizontal transfer and greatly limit its effects. We then show that allowing immigration completely changes these predictions. With migration, the rates and impacts of horizontal transfer are greatly increased, and transfer is most frequent for loci under positive natural selection. Our analysis explains how ecologically important loci can sweep through competing strains and species. In this way, microbial genomes can evolve to become ecologically diverse where different genomic regions encode for partially overlapping, but distinct, ecologies. Under these conditions ecological species do not exist, because genes, not species, inhabit niches.
Sujets

Bacteria/genetics

Gene Transfer, Horizo...

Genome, Bacterial

Models, Genetic

PID Serval
serval:BIB_9D710535D87B
DOI
PMID
WOS
Permalien
Open Access
Oui
Date de création
2016-01-04T09:00:47.060Z
Date de création dans IRIS
2025-05-20T22:40:29Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

26592443_BIB_9D710535D87B.pdf

Version du manuscrit

published

Licence

https://creativecommons.org/licenses/by/4.0

Taille

516.01 KB

Format

Adobe PDF

PID Serval

serval:BIB_9D710535D87B.P001

URN

urn:nbn:ch:serval-BIB_9D710535D87B5

Somme de contrôle

(MD5):b52681a4072ea3f988d79ae955743262