Titre
Are circulating endothelial-derived and platelet-derived microparticles a pathogenic factor in the cisplatin-induced stroke?
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Periard, D.
Auteure/Auteur
Boulanger, C. M.
Auteure/Auteur
Eyer, S.
Auteure/Auteur
Amabile, N.
Auteure/Auteur
Pugin, P.
Auteure/Auteur
Gerschheimer, C.
Auteure/Auteur
Hayoz, D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1524-4628
Statut éditorial
Publié
Date de publication
2007-05
Volume
38
Numéro
5
Première page
1636
Dernière page/numéro d’article
8
Notes
Journal Article --- Old month value: May
Résumé
BACKGROUND AND PURPOSE: To evaluate whether cisplatin-induced stroke is mediated by vascular toxicity with release of prothrombotic endothelial and platelet-derived microparticles (MPs). METHODS: Endothelial (CD31(+)CD41(-)), platelets (CD31(+)CD41(+)) and prothrombotic (Annexin V(+)) circulating MPs were quantified by flow cytometry in 18 patients with cancer, before and 3 days after administration of cisplatin, and compared with 18 healthy controls. Thrombin-antithrombin complex and prothrombin fragments (F(1+2)) were measured as markers of the activation of the coagulation. RESULTS: In patients with cancer, baseline levels of circulating prothrombotic, endothelial and platelet-derived MPs were similar to healthy controls and decreased significantly after administration of cisplatin. High-baseline MPs levels were observed in 5 patients who received cisplatin for a second or third cycle. A high-baseline activation of the coagulation was observed in all patients without further increase after cisplatin infusion. CONCLUSIONS: Cisplatin treatment is immediately followed by a decrease in circulating levels of endothelial and platelet-derived MPs. However, a transient increase in MPs is observed at the second and third infusion, and this may contribute to the cisplatin-induced stroke.
Sujets
PID Serval
serval:BIB_B31B6C3464F6
PMID
Open Access
Oui
Date de création
2008-01-17T15:38:08.327Z
Date de création dans IRIS
2025-05-20T23:43:06Z