Titre
Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Nuno-Perez, A.
Auteure/Auteur
Trusel, M.
Auteure/Auteur
Lalive, A.L.
Auteure/Auteur
Congiu, M.
Auteure/Auteur
Gastaldo, D.
Auteure/Auteur
Tchenio, A.
Auteure/Auteur
Lecca, S.
Auteure/Auteur
Soiza-Reilly, M.
Auteure/Auteur
Bagni, C.
Auteure/Auteur
Mameli, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1097-4199
Statut éditorial
Publié
Date de publication
2021-03-17
Volume
109
Numéro
6
Première page
947
Dernière page/numéro d’article
956.e5
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Weighing alternatives during reward pursuit is a vital cognitive computation that, when disrupted by stress, yields aspects of neuropsychiatric disorders. To examine the neural mechanisms underlying these phenomena, we employed a behavioral task in which mice were confronted by a reward and its omission (i.e., error). The experience of error outcomes engaged neuronal dynamics within the lateral habenula (LHb), a subcortical structure that supports appetitive behaviors and is susceptible to stress. A high incidence of errors predicted low strength of habenular excitatory synapses. Accordingly, stressful experiences increased error choices while decreasing glutamatergic neurotransmission onto LHb neurons. This synaptic adaptation required a reduction in postsynaptic AMPA receptors (AMPARs), irrespective of the anatomical source of glutamate. Bidirectional control of habenular AMPAR transmission recapitulated and averted stress-driven cognitive deficits. Thus, a subcortical synaptic mechanism vulnerable to stress underlies behavioral efficiency during cognitive performance.
PID Serval
serval:BIB_6CC094B1D075
PMID
Open Access
Oui
Date de création
2021-02-08T10:51:18.757Z
Date de création dans IRIS
2025-05-21T02:35:57Z
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Nom
33535028_BIB_6CC094B1D075.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
5.35 MB
Format
Adobe PDF
PID Serval
serval:BIB_6CC094B1D075.P001
URN
urn:nbn:ch:serval-BIB_6CC094B1D0758
Somme de contrôle
(MD5):6f13c239610581f460dbec89371dd504