Titre
Timing of onset of CKD-related metabolic complications
Type
article
Institution
Externe
Auteur(s)
Moranne, O.
Auteure/Auteur
Froissart, M.
Auteure/Auteur
Rossert, J.
Auteure/Auteur
Gauci, C.
Auteure/Auteur
Boffa, J. J.
Auteure/Auteur
Haymann, J. P.
Auteure/Auteur
M'Rad M, B.
Auteure/Auteur
Jacquot, C.
Auteure/Auteur
Houillier, P.
Auteure/Auteur
Stengel, B.
Auteure/Auteur
Fouqueray, B.
Auteure/Auteur
Groupes de travail
NephroTest Study Group
Liens vers les personnes
ISSN
1533-3450
Statut éditorial
Publié
Date de publication
2009
Volume
20
Numéro
1
Première page
164
Dernière page/numéro d’article
71
Langue
anglais
Notes
Moranne, Olivier
Froissart, Marc
Rossert, Jerome
Gauci, Cedric
Boffa, Jean-Jacques
Haymann, Jean Philippe
M'rad, Mona Ben
Jacquot, Christian
Houillier, Pascal
Stengel, Benedicte
Fouqueray, Bruno
eng
Research Support, Non-U.S. Gov't
2008/11/14 09:00
J Am Soc Nephrol. 2009 Jan;20(1):164-71. doi: 10.1681/ASN.2008020159. Epub 2008 Nov 12.
Froissart, Marc
Rossert, Jerome
Gauci, Cedric
Boffa, Jean-Jacques
Haymann, Jean Philippe
M'rad, Mona Ben
Jacquot, Christian
Houillier, Pascal
Stengel, Benedicte
Fouqueray, Bruno
eng
Research Support, Non-U.S. Gov't
2008/11/14 09:00
J Am Soc Nephrol. 2009 Jan;20(1):164-71. doi: 10.1681/ASN.2008020159. Epub 2008 Nov 12.
Résumé
Chronic kidney disease (CKD) guidelines recommend evaluating patients with GFR <60 ml/min per 1.73 m(2) for complications, but little evidence supports the use of a single GFR threshold for all metabolic disorders. We used data from the NephroTest cohort, including 1038 adult patients who had stages 2 through 5 CKD and were not on dialysis, to study the occurrence of metabolic complications. GFR was measured using renal clearance of (51)Cr-EDTA (mGFR) and estimated using two equations derived from the Modification of Diet in Renal Disease study. As mGFR decreased from 60 to 90 to <20 ml/min per 1.73 m(2), the prevalence of hyperparathyroidism increased from 17 to 85%, anemia from 8 to 41%, hyperphosphatemia from 1 to 30%, metabolic acidosis from 2 to 39%, and hyperkalemia from 2 to 42%. Factors most strongly associated with metabolic complications, independent of mGFR, were younger age for acidosis and hyperphosphatemia, presence of diabetes for acidosis, diabetic kidney disease for anemia, and both male gender and the use of inhibitors of the renin-angiotensin system for hyperkalemia. mGFR thresholds for detecting complications with 90% sensitivity were 50, 44, 40, 39, and 37 ml/min per 1.73 m(2) for hyperparathyroidism, anemia, acidosis, hyperkalemia, and hyperphosphatemia, respectively. Analysis using estimated GFR produced similar results. In summary, this study describes the onset of CKD-related complications at different levels of GFR; anemia and hyperparathyroidism occur earlier than acidosis, hyperkalemia, and hyperphosphatemia.
PID Serval
serval:BIB_D30FBF17D360
URL éditeur
Open Access
Oui
Date de création
2016-03-03T15:48:58.171Z
Date de création dans IRIS
2025-05-20T22:52:56Z