Titre
Understanding what makes a good versus a bad vaccine
Type
éditorial
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Harari, A.
Auteure/Auteur
Pantaleo, G.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0014-2980
Statut éditorial
Publié
Date de publication
2005-09
Volume
35
Numéro
9
Première page
2528
Dernière page/numéro d’article
31
Notes
Comment
Journal Article --- Old month value: Sep
Journal Article --- Old month value: Sep
Résumé
The majority of the HIV vaccines under development are aimed at stimulating T cell responses. Therefore, it is critical to delineate the factors regulating the generation of the T cell responses and to develop strategies maximizing vaccine-induced T cell responses. The identification of these factors and the delineation of the kinetics of the generation of vaccine-induced immune responses have been hard to investigate, due to the limited number of precursor naive antigen-specific T cells. To overcome these obstacles, Estcourt and collaborators have developed an elegant strategy that consists of an in vivo mouse model employing transfer of naive CFSE-labeled TCR-transgenic T lymphocytes into syngeneic nontransgenic recipients prior to vaccination. Using this model, the authors demonstrate that the dose, the route of administration and the type of vaccine determine the magnitude, the dissemination and the kinetics of vaccine-induced T cell responses. Furthermore, the mouse model of Estcourt and collaborators may represent the basis for the development of powerful in vivo experimental strategies to evaluate vaccine candidates.
Sujets
PID Serval
serval:BIB_FE51441F1B0A
PMID
Open Access
Oui
Date de création
2008-01-25T14:00:44.365Z
Date de création dans IRIS
2025-05-21T06:40:11Z