Titre
Erosion of the temporal bone by vestibular schwannoma: morphometrics and predictive modeling.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Massager, N.
Auteure/Auteur
El Hadwe, S.
Auteure/Auteur
Barrit, S.
Auteure/Auteur
Al Barajraji, M.
Auteure/Auteur
Morelli, D.
Auteure/Auteur
Renier, C.
Auteure/Auteur
Liens vers les unités
ISSN
1434-4726
Statut éditorial
Publié
Date de publication
2025-03
Volume
282
Numéro
3
Première page
1271
Dernière page/numéro d’article
1279
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
To perform a comprehensive morphometric analysis of vestibular schwannomas (VS) using multimodal imaging, focusing on the relationship between tumor characteristics and internal acoustic canal (IAC) changes.
We analyzed a cohort of patients undergoing radiosurgery for VS, utilizing high-definition MRI and bone CT for detailed anatomical assessment. Image co-registration and fusion techniques were employed to examine VS and IAC dimensions. Advanced statistical methods, including logistic regression, were applied to identify patterns of IAC dilation and establish predictive indicators for these morphological changes.
The study included 659 patients (51.1% female, mean age 56.37 years) with evenly distributed tumor lateralization. Koos grades were I (22.9%), II (29.9%), III (38.2%), IVa (8.9%), and IVb (0.3%). Most tumors (90.9%) extended both inside and outside the IAC. Ipsilateral IAC (IIAC) dimensions were significantly larger than contralateral, with IIAC volume 49% greater (p < .0001). Higher Koos grades correlated with increased intra-canalicular lesion volume (icLV), which was strongly associated with IIAC size. Logistic regression identified icLV as the strongest predictor of IIAC dilation (AUC = 0.7674, threshold = 137.52 mm3).
The icLV appears central to the pathophysiological development of VS and its impact on IAC anatomy. While limited by a selective patient base and static imaging data, these findings enhance the understanding of VS-IAC interactions, offering insights for improved clinical management and further research.
We analyzed a cohort of patients undergoing radiosurgery for VS, utilizing high-definition MRI and bone CT for detailed anatomical assessment. Image co-registration and fusion techniques were employed to examine VS and IAC dimensions. Advanced statistical methods, including logistic regression, were applied to identify patterns of IAC dilation and establish predictive indicators for these morphological changes.
The study included 659 patients (51.1% female, mean age 56.37 years) with evenly distributed tumor lateralization. Koos grades were I (22.9%), II (29.9%), III (38.2%), IVa (8.9%), and IVb (0.3%). Most tumors (90.9%) extended both inside and outside the IAC. Ipsilateral IAC (IIAC) dimensions were significantly larger than contralateral, with IIAC volume 49% greater (p < .0001). Higher Koos grades correlated with increased intra-canalicular lesion volume (icLV), which was strongly associated with IIAC size. Logistic regression identified icLV as the strongest predictor of IIAC dilation (AUC = 0.7674, threshold = 137.52 mm3).
The icLV appears central to the pathophysiological development of VS and its impact on IAC anatomy. While limited by a selective patient base and static imaging data, these findings enhance the understanding of VS-IAC interactions, offering insights for improved clinical management and further research.
Sujets
PID Serval
serval:BIB_C04FDCE27C69
PMID
Date de création
2024-10-28T13:19:00.514Z
Date de création dans IRIS
2025-05-20T23:20:28Z