Titre
Polyclonal intravenous immune globulin for prevention and treatment of infections in critically ill patients
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Cometta, A.
Auteure/Auteur
Baumgartner, J. D.
Auteure/Auteur
Glauser, M. P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0009-9104
Statut éditorial
Publié
Date de publication
1994-07
Volume
97 Suppl 1
Première page
69
Dernière page/numéro d’article
72
Notes
Comparative Study
Journal Article
Review --- Old month value: Jul
Journal Article
Review --- Old month value: Jul
Résumé
Infections remain the leading cause of death among patients admitted to intensive care units (ICU). Infections due to Gram-negative bacteria are both frequent and difficult to treat. The poor outcome of such infections has been attributed to the endotoxin. The high mortality rate related to Gram-negative sepsis has prompted the testing of new, adjunctive therapies to prevent and treat infections in critically ill patients. Immunotherapy or immunoprophylaxis have long been investigated in this context. Passive immunotherapy consists of the administration of immune plasma or serum, or standard or hyperimmune purified immune globulins. Several clinical studies using such preparations to treat critically ill patients are reviewed in this article. While two studies using hyperimmune plasma or serum appeared to be successful, two studies using hyperimmune globulin failed to show a beneficial effect in the treatment or the prevention of Gram-negative septic shock. Regarding the infusion of standard intravenous immune globulin (IVIG) two studies have demonstrated a substantial benefit in the prevention of severe infections; the reduction of nosocomial pneumonia recorded in both trials and the shortness of stay in ICU may also afford savings in hospital costs. The cost effectiveness of such prophylactic administration of IVIG is worthy of further investigation.
Sujets
PID Serval
serval:BIB_6C60880D886E
PMID
Date de création
2008-01-25T12:31:24.437Z
Date de création dans IRIS
2025-05-21T02:35:38Z