Titre
Overweight and obesity in adult patients with phenylketonuria: a systematic review.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Tankeu, A.T.
Auteure/Auteur
Pavlidou, D.C.
Auteure/Auteur
Superti-Furga, A.
Auteure/Auteur
Gariani, K.
Auteure/Auteur
Tran, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1750-1172
Statut éditorial
Publié
Date de publication
2023-02-22
Volume
18
Numéro
1
Première page
37
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Excess weight is a rising concern in patients with phenylketonuria (PKU). It is commonly observed in children and adolescents with PKU; but data on adults are inconsistent. This review aims to summarize available data on excess weight in adult PKU individuals.
We conducted a systematic search of literature in English, from inception to October 2021, on PubMed and Embase to identify articles on overweight and obesity in adult PKU patients. Prevalence of overweight and obesity, body mass index (BMI) and gender differences were the outcomes of interest.
Of 260 articles identified, only 8 fulfilled quality criteria for inclusion after screening of titles, abstracts and full texts. The mean BMI of adult PKU patients in these studies ranged from 26 ± 5.4 to 30.3 ± 1.8 kg/m <sup>2</sup> . When compared to matched controls, adult PKU patients had higher BMI and higher prevalence of obesity. However, results were inconsistent when PKU adults were compared to the general population. The prevalence of obesity in the included studies varied widely between 4.5% up to 72% in individual studies. Obesity was 2-3 times more frequent in female PKU patients.
Excess weight is frequent in adult PKU patients, especially in females, even if the difference with the general population is debatable. The heterogeneity of the studies makes it difficult to interpret the results and the factors that contribute to obesity. Content of the diet, psychological status, diet-associated disordered eating, patient's social environment and lifestyle are listed as potentials contributors to excess weight in PKU adult population. Further studies are needed to better elucidate this question. In the meantime, weight control and healthy eating habits should be considered in the management and follow-up of these patients.
We conducted a systematic search of literature in English, from inception to October 2021, on PubMed and Embase to identify articles on overweight and obesity in adult PKU patients. Prevalence of overweight and obesity, body mass index (BMI) and gender differences were the outcomes of interest.
Of 260 articles identified, only 8 fulfilled quality criteria for inclusion after screening of titles, abstracts and full texts. The mean BMI of adult PKU patients in these studies ranged from 26 ± 5.4 to 30.3 ± 1.8 kg/m <sup>2</sup> . When compared to matched controls, adult PKU patients had higher BMI and higher prevalence of obesity. However, results were inconsistent when PKU adults were compared to the general population. The prevalence of obesity in the included studies varied widely between 4.5% up to 72% in individual studies. Obesity was 2-3 times more frequent in female PKU patients.
Excess weight is frequent in adult PKU patients, especially in females, even if the difference with the general population is debatable. The heterogeneity of the studies makes it difficult to interpret the results and the factors that contribute to obesity. Content of the diet, psychological status, diet-associated disordered eating, patient's social environment and lifestyle are listed as potentials contributors to excess weight in PKU adult population. Further studies are needed to better elucidate this question. In the meantime, weight control and healthy eating habits should be considered in the management and follow-up of these patients.
PID Serval
serval:BIB_920FF2B6A864
PMID
Open Access
Oui
Date de création
2023-02-27T16:24:32.106Z
Date de création dans IRIS
2025-05-21T03:21:39Z
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Nom
13023_2023_Article_2636.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
772.17 KB
Format
Adobe PDF
PID Serval
serval:BIB_920FF2B6A864.P001
URN
urn:nbn:ch:serval-BIB_920FF2B6A8643
Somme de contrôle
(MD5):fb26fb8ddde485b6b42d4974f46d3b42