Titre
The differential impact of duration of untreated psychosis on functioning and quality of life: A threshold analysis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Golay, P.
Auteure/Auteur
Ramain, J.
Auteure/Auteur
Mebdouhi, N.
Auteure/Auteur
Abrahamyan Empson, L.
Auteure/Auteur
Elowe, J.
Auteure/Auteur
Solida, A.
Auteure/Auteur
Conus, P.
Auteure/Auteur
Liens vers les personnes
ISSN
1751-7893
Statut éditorial
Publié
Date de publication
2023-04
Volume
17
Numéro
4
Première page
354
Dernière page/numéro d’article
360
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Reduction of duration of untreated psychosis (DUP) remains a key goal of early intervention programs. While a significant body of literature suggests that a short DUP has a positive impact on outcome, little is known regarding the threshold above which various dimensions of outcome are impaired. In this study, we explore the DUP threshold that best discriminates subgroups with poorer outcome regarding global functioning and quality of life after 3 years of treatment.
A total of 432 patients were followed-up prospectively over 3 years. Several hypothetical cut-off points for DUP were tested in order to maximize differences in effect size for quality of life and general functioning.
While a DUP cut-off of 86 weeks defined two subpopulations with a difference of greatest effect size in quality of life after 3 years, it is already at a cut-off of 3 weeks of DUP that two subpopulations with a difference in global functioning of the greatest effect size was reached.
DUP seems to have a differential impact on the various components of outcome, and in particular on quality of life and global functioning. Our data suggest that aiming at very short DUP is justified, but that DUP over 3 weeks are still compatible with good quality of life after 3 years of treatment.
A total of 432 patients were followed-up prospectively over 3 years. Several hypothetical cut-off points for DUP were tested in order to maximize differences in effect size for quality of life and general functioning.
While a DUP cut-off of 86 weeks defined two subpopulations with a difference of greatest effect size in quality of life after 3 years, it is already at a cut-off of 3 weeks of DUP that two subpopulations with a difference in global functioning of the greatest effect size was reached.
DUP seems to have a differential impact on the various components of outcome, and in particular on quality of life and global functioning. Our data suggest that aiming at very short DUP is justified, but that DUP over 3 weeks are still compatible with good quality of life after 3 years of treatment.
PID Serval
serval:BIB_464B770AAEF6
PMID
Open Access
Oui
Date de création
2022-05-30T07:02:57.124Z
Date de création dans IRIS
2025-05-20T14:07:56Z
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Nom
Golay et al. in press.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
921.65 KB
Format
Adobe PDF
PID Serval
serval:BIB_464B770AAEF6.P001
URN
urn:nbn:ch:serval-BIB_464B770AAEF62
Somme de contrôle
(MD5):53ee619a963a5eef79fba822e0e487c1