Titre
Forced diuresis improves the diagnostic accuracy of 18F-FDG PET in abdominopelvic malignancies.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Kamel, E.M.
Auteure/Auteur
Jichlinski, P.
Auteure/Auteur
Prior, J.O.
Auteure/Auteur
Meuwly, J.Y.
Auteure/Auteur
Delaloye, J.F.
Auteure/Auteur
Vaucher, L.
Auteure/Auteur
Malterre, J.
Auteure/Auteur
Castaldo, S.
Auteure/Auteur
Leisinger, H.J.
Auteure/Auteur
Delaloye, A.B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0161-5505
Statut éditorial
Publié
Date de publication
2006
Volume
47
Numéro
11
Première page
1803
Dernière page/numéro d’article
7
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article - Publication Status: ppublish
Résumé
Our aim was to evaluate the role of forced diuresis in improving the diagnostic accuracy of abdominopelvic (18)F-FDG PET. METHODS: Thirty-two patients were enrolled. Besides the presence of known intravesical tumors or undefined renal lesions on the initial PET scan, the inclusion criterion was the appearance of indeterminate or equivocal (18)F-FDG foci that extended along the course of the urinary tract and could not confidently be separated from urinary activity. For each patient, a second abdominopelvic PET study was performed after intravenous injection of 0.5 mg of furosemide per kilogram of body weight (maximum, 40 mg) coupled with parenteral infusion of physiologic saline. RESULTS: Forced diuresis coupled with parenteral hydration eliminated any significant (18)F-FDG activity from the lower urinary tract in 31 (97%) of 32 patients after the bladder had been voided 3 successive times. Twelve intravesical lesions were visualized with outstanding clarity, whereas radiologic suspicion of locally recurrent bladder tumors was ruled out in 3 patients. Among 14 indeterminate or equivocal extravesical foci, 7 were deemed of no clinical value because they disappeared after furosemide challenge, whereas 7 persisting foci were proven to be true-positive PET findings. The performance of (18)F-FDG PET in characterizing 3 renal-space-occupying lesions could not be improved by our protocol. CONCLUSION: Furosemide challenge has the potential to noninvasively resolve the inherent (18)F-FDG contrast handicap in the lower urinary tract.
PID Serval
serval:BIB_75558EB25D84
PMID
Date de création
2008-02-27T15:31:42.909Z
Date de création dans IRIS
2025-05-20T22:28:43Z