Titre
Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Borcel, E.
Auteure/Auteur
Palczynska, M.
Auteure/Auteur
Krzisch, M.
Auteure/Auteur
Dimitrov, M.
Auteure/Auteur
Ulrich, G.
Auteure/Auteur
Toni, N.
Auteure/Auteur
Fraering, P.C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2045-2322
Statut éditorial
Publié
Date de publication
2016-12-19
Volume
6
Première page
39310
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Neurexins are transmembrane synaptic cell adhesion molecules involved in the development and maturation of neuronal synapses. In the present study, we report that Nrxn3β is processed by the metalloproteases ADAM10, ADAM17, and by the intramembrane-cleaving protease γ-secretase, producing secreted neurexin3β (sNrxn3β) and a single intracellular domain (Nrxn3β-ICD). We further completed the full characterization of the sites at which Nrxn3β is processed by these proteases. Supporting the physiological relevance of the Nrxn3β processing, we demonstrate in vivo a significant effect of the secreted shedding product sNrxn3β on the morphological development of adult newborn neurons in the mouse hippocampus. We show that sNrxn3β produced by the cells of the dentate gyrus increases the spine density of newborn neurons whereas sNrxn3β produced by the newborn neuron itself affects the number of its mossy fiber terminal extensions. These results support a pivotal role of sNrxn3β in plasticity and network remodeling during neuronal development.
PID Serval
serval:BIB_0BE7AFEF79E9
PMID
Open Access
Oui
Date de création
2016-12-29T08:23:05.513Z
Date de création dans IRIS
2025-05-20T17:05:55Z
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Nom
27991559.pdf
Version du manuscrit
published
Taille
1.66 MB
Format
Adobe PDF
PID Serval
serval:BIB_0BE7AFEF79E9.P001
URN
urn:nbn:ch:serval-BIB_0BE7AFEF79E91
Somme de contrôle
(MD5):928dee37bf090b5d17c82a2c49d396f5