Titre
Impact of aerobic exercise type on blood flow, muscle energy metabolism, and mitochondrial biogenesis in experimental lower extremity artery disease.
Type
éditorial
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Pellegrin, M.
Auteure/Auteur
Bouzourène, K.
Auteure/Auteur
Aubert, J.F.
Auteure/Auteur
Bielmann, C.
Auteure/Auteur
Gruetter, R.
Auteure/Auteur
Rosenblatt-Velin, N.
Auteure/Auteur
Poitry-Yamate, C.
Auteure/Auteur
Mazzolai, L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2045-2322
Statut éditorial
Publié
Date de publication
2020-08-20
Volume
10
Numéro
1
Première page
14048
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Exercise training (ET) is recommended for lower extremity artery disease (LEAD) management. However, there is still little information on the hemodynamic and metabolic adaptations by skeletal muscle with ET. We examined whether hindlimb perfusion/vascularization and muscle energy metabolism are altered differently by three types of aerobic ET. ApoE <sup>-/-</sup> mice with LEAD were assigned to one of four groups for 4 weeks: sedentary (SED), forced treadmill running (FTR), voluntary wheel running (VWR), or forced swimming (FS). Voluntary exercise capacity was improved and equally as efficient with FTR and VWR, but remained unchanged with FS. Neither ischemic hindlimb perfusion and oxygenation, nor arteriolar density and mRNA expression of arteriogenic-related genes differed between groups. <sup>18</sup> FDG PET imaging revealed no difference in the steady-state levels of phosphorylated <sup>18</sup> FDG in ischemic and non-ischemic hindlimb muscle between groups, nor was glycogen content or mRNA and protein expression of glucose metabolism-related genes in ischemic muscle modified. mRNA (but not protein) expression of lipid metabolism-related genes was upregulated across all exercise groups, particularly by non-ischemic muscle. Markers of mitochondrial content (mitochondrial DNA content and citrate synthase activity) as well as mRNA expression of mitochondrial biogenesis-related genes in muscle were not increased with ET. Contrary to FTR and VWR, swimming was ineffective in improving voluntary exercise capacity. The underlying hindlimb hemodynamics or muscle energy metabolism are unable to explain the benefits of running exercise.
PID Serval
serval:BIB_4E558217EFB1
PMID
Open Access
Oui
Date de création
2020-09-03T09:41:01.111Z
Date de création dans IRIS
2025-05-20T16:59:12Z
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Nom
32820213_BIB_4E558217EFB1.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.82 MB
Format
Adobe PDF
PID Serval
serval:BIB_4E558217EFB1.P001
URN
urn:nbn:ch:serval-BIB_4E558217EFB19
Somme de contrôle
(MD5):5bbe179b43b78e64dc9e5c93b3e33f61