Titre
Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapies.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Pasquini, M.
Auteure/Auteur
James, N.D.
Auteure/Auteur
Dewany, I.
Auteure/Auteur
Coen, F.V.
Auteure/Auteur
Cho, N.
Auteure/Auteur
Lai, S.
Auteure/Auteur
Anil, S.
Auteure/Auteur
Carpaneto, J.
Auteure/Auteur
Barraud, Q.
Auteure/Auteur
Lacour, S.P.
Auteure/Auteur
Micera, S.
Auteure/Auteur
Courtine, G.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2470-9476
Statut éditorial
Publié
Date de publication
2022-03-30
Volume
7
Numéro
64
Première page
eabk2378
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Numerous neurorehabilitative, neuroprosthetic, and repair interventions aim to address the consequences of upper limb impairments after neurological disorders. Although these therapies target widely different mechanisms, they share the common need for a preclinical platform that supports the development, assessment, and understanding of the therapy. Here, we introduce a neurorobotic platform for rats that meets these requirements. A four-degree-of-freedom end effector is interfaced with the rat's wrist, enabling unassisted to fully assisted execution of natural reaching and retrieval movements covering the entire body workspace. Multimodal recording capabilities permit precise quantification of upper limb movement recovery after spinal cord injury (SCI), which allowed us to uncover adaptations in corticospinal tract neuron dynamics underlying this recovery. Personalized movement assistance supported early neurorehabilitation that improved recovery after SCI. Last, the platform provided a well-controlled and practical environment to develop an implantable spinal cord neuroprosthesis that improved upper limb function after SCI.
PID Serval
serval:BIB_384E54C8E47A
PMID
Date de création
2022-05-13T16:40:57.047Z
Date de création dans IRIS
2025-05-20T19:19:32Z