Titre
Permeability of the developing and mature blood-brain barriers to theophylline in rats
Type
article
Institution
Externe
Auteur(s)
Habgood, M. D.
Auteure/Auteur
Knott, G. W.
Auteure/Auteur
Dziegielewska, K. M.
Auteure/Auteur
Saunders, N. R.
Auteure/Auteur
Liens vers les personnes
ISSN
0305-1870
Statut éditorial
Publié
Date de publication
1998-05
Volume
25
Numéro
5
Première page
361
Dernière page/numéro d’article
8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
1. In the present study, the uptake of theophylline and L-glucose into the adult and neonatal rat brain has been investigated. Steady state cerebrospinal fluid (CSF) and brain concentrations of theophylline were reached within 1 h following a single intraperitoneal (i.p.) injection, whereas steady state CSF and brain concentrations of L-glucose were not approached until after 5 h. 2. Steady state brain:plasma and CSF:plasma concentration ratios for theophylline and L-glucose in neonatal rats were significantly higher than ratios in adult rats. Erythrocyte:plasma ratios for theophylline in neonatal rats were also significantly higher than ratios in adult rats. Steady state ratios for theophylline were significantly higher than those for L-glucose in both neonatal and adult rats. 3. Respiratory acidosis (pH 6.9-7.0) did not affect steady state CSF:plasma or brain:plasma ratios for theophylline in neonatal or adult rats. In contrast, steady state CSF:plasma and brain:plasma ratios for L-glucose were increased by respiratory acidosis. 4. The lower steady state CSF:plasma, brain:plasma and erythrocyte:plasma ratios for theophylline in adult rats are likely to be due to a higher concentration of plasma proteins in adult blood compared with neonates, with a greater retention of protein-bound (non-exchangeable) theophylline in adult blood, and are unlikely to be due to p-glycoprotein-mediated efflux of theophylline at the adult blood-brain barrier.
Sujets
PID Serval
serval:BIB_DDB7150E4C16
PMID
Date de création
2008-01-24T13:26:17.394Z
Date de création dans IRIS
2025-05-21T05:11:32Z