Titre
Targeting of secretory IgA to Peyer's patch dendritic and T cells after transport by intestinal M cells.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Rey, J.
Auteure/Auteur
Garin, N.
Auteure/Auteur
Spertini, F.
Auteure/Auteur
Corthésy, B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0022-1767[print], 0022-1767[linking]
Statut éditorial
Publié
Date de publication
2004
Volume
172
Numéro
5
Première page
3026
Dernière page/numéro d’article
3033
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
In addition to being instrumental to the protection of mucosal epithelia, secretory IgA (SIgA) adheres to and is transported by intestinal Peyer's patch (PP) M cells. The possible functional reason for this transport is unknown. We have thus examined in mice the outcome of SIgA delivered from the intestinal lumen to the cells present in the underlying organized mucosa-associated lymphoreticular tissue. We show selective association of SIgA with dendritic cells and CD4(+) T and B lymphocytes recovered from PP in vitro. In vivo, exogenously delivered SIgA is able to enter into multiple PP lining the intestine. In PP, SIgA associates with and is internalized by dendritic cells in the subepithelial dome region, whereas the interaction with CD4(+) T cells is limited to surface binding. Interaction between cells and SIgA is mediated by the IgA moiety and occurs for polymeric and monomeric molecular forms. Thus, although immune exclusion represents the main function of SIgA, transport of the Ab by M cells might promote Ag sampling under neutralizing conditions essential to the homeostasis of mucosal surfaces.
Sujets
PID Serval
serval:BIB_059C9FA09817
PMID
Date de création
2008-01-25T13:53:11.711Z
Date de création dans IRIS
2025-05-20T19:06:59Z