Titre
New-onset obesity after liver transplantation-outcomes and risk factors: the Swiss Transplant Cohort Study.
Type
étude de cas
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Beckmann, S.
Auteure/Auteur
Denhaerynck, K.
Auteure/Auteur
Stampf, S.
Auteure/Auteur
Saigi-Morgui, N.
Auteure/Auteur
Binet, I.
Auteure/Auteur
Koller, M.
Auteure/Auteur
Boely, E.
Auteure/Auteur
De Geest, S.
Auteure/Auteur
Contributrices/contributeurs
Helmy, R.
Leppla, L.
Luta, X.
Mauthner, O.
Struker, M.
Boehler, A.
Gerull, S.
Berben, L.
Huynh-Do, U.
Catana, E.
Seiler, A.
Klaghofer, R.
Künzler-Heule, P.
Burkhalter, H.
Achermann, R.
Amico, P.
Aubert, J.D.
Banz, V.
Beldi, G.
Benden, C.
Berger, C.
Bochud, P.Y.
Bucher, H.
Carell, T.
Catana, E.
Chalandon, Y.
de Rougemont, O.
Dickenmann, M.
Duchosal, M.
Elkrief, L.
Fehr, T.
Ferrari-Lacraz, S.
Garzoni, C.
Soccal, P.G.
Gaudet, C.
Giostra, E.
Golshayan, D.
Hadaya, K.
Halter, J.
Heim, D.
Hess, C.
Hillinger, S.
Hirsch, H.H.
Hofbauer, G.
Huynh-Do, U.
Immer, F.
Klaghofer, R.
Laesser, B.
Lehmann, R.
Lovis, C.
Majno, P.
Manuel, O.
Marti, H.P.
Martin, P.Y.
Meylan, P.
Mohacsi, P.
Morel, P.
Mueller, U.
Mueller, N.J.
Mueller-McKenna, H.
Müller, A.
Müller, T.
Müllhaupt, B.
Nadal, D.
Pascual, M.
Passweg, J.
Rick, J.
Roosnek, E.
Rosselet, A.
Rothlin, S.
Ruschitzka, F.
Schanz, U.
Schaub, S.
Schnyder, A.
Seiler, C.
Steiger, J.
Stirnimann, G.
Toso, C.
Van Delden, C.
Venetz, J.P.
Villard, J.
Wick, M.
Wilhelm, M.
Yerly, P.
Groupes de travail
Psychosocial Interest Group
Swiss Transplant Cohort Study
Liens vers les personnes
Liens vers les unités
ISSN
1432-2277
Statut éditorial
Publié
Date de publication
2018-11
Volume
31
Numéro
11
Première page
1254
Dernière page/numéro d’article
1267
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Weight gain after liver transplantation (LTx) facilitates development of new-onset obesity; however, its risk factors and outcomes are poorly understood. We identified the impact of new-onset obesity on cardiovascular events (CVEs) and patient survival, and risk factors for new-onset obesity. Multiple Cox regression models examined risk factors for CVEs, patient survival, and new-onset obesity in 253 adults (mean age 52.2 ± 11.6 years, male gender 63.6%, mean follow up 5.7 ± 2.1 years). Cumulative incidence of post-LTx CVE was 28.1%; that of new-onset obesity was 21.3%. Regardless of CVE at LTx, post-LTx CVEs were predicted by new-onset obesity [Hazard Ratio (HR), 2.95; P = 0.002] and higher age at LTx (HR, 1.05; P < 0.001). In patients without known pre-LTx CVEs (n = 214), risk factors for post-LTx CVEs were new-onset obesity (HR, 2.59; P = 0.014) and higher age (HR, 1.04; P = 0.001). Survival was not associated with new-onset obesity (P = 0.696). Alcoholic liver disease predicted new-onset obesity (HR, 3.37; P = 0.025), female gender was protective (HR, 0.39; P = 0.034). In 114 patients with available genetic data, alcoholic liver disease (HR, 12.82; P = 0.014) and hepatocellular carcinoma (HR, 10.02; P = 0.048) predicted new-onset obesity, and genetics remained borderline significant (HR, 1.07; P = 0.071). Early introduction of post-LTx weight management programs may suggest a potential pathway to reduce CVE risk.
PID Serval
serval:BIB_939EA1F073F3
PMID
Date de création
2018-07-17T13:04:56.933Z
Date de création dans IRIS
2025-05-21T03:22:28Z