Titre
Hypoglycemies induites par les sulfamides hypoglycemiants. Recensement par les Centres Regionaux de Pharmacovigilance francais de 1985 a 1990. [Hypoglycemia induced by oral hypoglycemic agents. Records of the French Regional Pharmacovigilance Centers 1985-1990]
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Annales de Medecine Interne
Auteur(s)
Girardin, E.
Auteure/Auteur
Vial, T.
Auteure/Auteur
Pham, E.
Auteure/Auteur
Evreux, J. C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0003-410X
Statut éditorial
Publié
Date de publication
1992
Volume
143
Numéro
1
Première page
11
Dernière page/numéro d’article
7
Peer-reviewed
Oui
Notes
English Abstract
Journal Article
Journal Article
Résumé
All 98 cases of sulfonylurea-induced hypoglycemia reported by the 30 regional drug-monitoring centers between 1985 and 1990 were analyzed: 46 with gliclazide, 40 with glibenclamide, 5 with glipizide, 1 with glibornuride and 6 with first-generation sulfonylureas. These cases of hypoglycemia were often serious. The patients were 61% female and their mean age was 78.9 years. The average number of medications being taken was 3.4, but ranged up to 14. The risk factors were: reduced food intake (4.2%), renal failure (4.2%), prescription error (3.2%), voluntary or accidental overdose (5.2%), alcohol (1.1%), suspected drug interactions (50%), unknown (32.6%). The most frequent drug interactions involved miconazole (8 cases), angiotensin-converting enzyme inhibitors (9 cases), lipid-regulating agents (fibrates) (7 cases), co-trimoxazole (trimethoprim-sulfamethoxazole; 5 cases), metformin (4 cases), histamine H2-receptor antagonists (4 cases). The mechanisms of these interactions are discussed.
Sujets
PID Serval
serval:BIB_2C47EB264F24
PMID
Date de création
2008-01-15T13:28:01.263Z
Date de création dans IRIS
2025-05-20T15:27:15Z