Titre
A critical re-examination of sexual dimorphism in the corpus callosum microstructure.
Type
article
Institution
Externe
Périodique
Auteur(s)
Westerhausen, R.
Auteure/Auteur
Kompus, K.
Auteure/Auteur
Dramsdahl, M.
Auteure/Auteur
Falkenberg, L.E.
Auteure/Auteur
Grüner, R.
Auteure/Auteur
Hjelmervik, H.
Auteure/Auteur
Specht, K.
Auteure/Auteur
Plessen, K.
Auteure/Auteur
Hugdahl, K.
Auteure/Auteur
Liens vers les personnes
ISSN
1095-9572
Statut éditorial
Publié
Date de publication
2011-06-01
Volume
56
Numéro
3
Première page
874
Dernière page/numéro d’article
880
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Recent diffusion-tensor imaging (DTI) studies suggest sexual dimorphism in the micro-structural architecture of the corpus callosum. However, the corpus callosum is also found to be larger in males than in females, a fact that might introduce a systematic bias to the analysis of DTI parameters. Diffusion parameters obtained in the larger male corpus callosum could be less affected by partial-volume averaging with surrounding non-callosal tissue than respective parameters obtained in the smaller female corpus callosum, i.e. the sex of the subject and partial-volume effects would be confounded. The objective of the present DTI study was to re-examine microstructural sex differences in the corpus callosum, while controlling for corpus callosum size differences between sexes. We compared 41 female and 34 male participants using regional tract-based spatial statistics (TBSS) analysis. Clusters of significantly higher fractional anisotropy (FA) and lower diffusion strength in males compared to females were detected in the genu and truncus of the corpus callosum. However, only the sex difference located in the anterior genu subregions could be unequivocally interpreted. This was the only cluster where the diffusion parameters did not correlate with regional callosal size. The present results indicate a stronger inter-hemispheric connectivity between the frontal lobes in males than females, which might be related to sex differences in hemispheric asymmetry and brain size.
PID Serval
serval:BIB_8048CE5CB501
PMID
Date de création
2019-02-21T08:25:54.529Z
Date de création dans IRIS
2025-05-20T21:58:21Z