Titre
DDR1 role in fibrosis and its pharmacological targeting.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Moll, S.
Auteure/Auteur
Desmoulière, A.
Auteure/Auteur
Moeller, M.J.
Auteure/Auteur
Pache, J.C.
Auteure/Auteur
Badi, L.
Auteure/Auteur
Arcadu, F.
Auteure/Auteur
Richter, H.
Auteure/Auteur
Satz, A.
Auteure/Auteur
Uhles, S.
Auteure/Auteur
Cavalli, A.
Auteure/Auteur
Drawnel, F.
Auteure/Auteur
Scapozza, L.
Auteure/Auteur
Prunotto, M.
Auteure/Auteur
Liens vers les unités
ISSN
1879-2596
Statut éditorial
Publié
Date de publication
2019-11
Volume
1866
Numéro
11
Première page
118474
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung. DDR1's biology is elusive, with unknown downstream activation pathways; however, it may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts. Increased expression of DDR1 has been documented in several types of cancer and fibrotic conditions including skin hypertrophic scars, idiopathic pulmonary fibrosis, cirrhotic liver and renal fibrosis. The present review article focuses on: a) detailing the evidence for a role of DDR1 as an anti-fibrotic target in different organs, b) clarifying DDR1 tissue distribution in healthy and diseased tissues as well as c) exploring DDR1 protective mode of action based on literature evidence and co-authors experience; d) detailing pharmacological efforts attempted to drug this subtle anti-fibrotic target to date.
Sujets
PID Serval
serval:BIB_25F81C67012D
PMID
Date de création
2019-04-15T16:40:40.931Z
Date de création dans IRIS
2025-05-20T19:09:48Z