Titre
Patients presenting with metastases: stage IV uveal melanoma, an international study.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Garg, G.
Auteure/Auteur
Finger, P.T.
Auteure/Auteur
Kivelä, T.T.
Auteure/Auteur
Simpson, E.R.
Auteure/Auteur
Gallie, B.L.
Auteure/Auteur
Saakyan, S.
Auteure/Auteur
Amiryan, A.G.
Auteure/Auteur
Valskiy, V.
Auteure/Auteur
Chin, K.J.
Auteure/Auteur
Semenova, E.
Auteure/Auteur
Seregard, S.
Auteure/Auteur
Filì, M.
Auteure/Auteur
Wilson, M.
Auteure/Auteur
Haik, B.
Auteure/Auteur
Caminal, J.M.
Auteure/Auteur
Catala-Mora, J.
Auteure/Auteur
Gutiérrez, C.
Auteure/Auteur
Pelayes, D.E.
Auteure/Auteur
Folgar, A.M.
Auteure/Auteur
Jager, M.J.
Auteure/Auteur
Doğrusöz, M.
Auteure/Auteur
Luyten, GPM
Auteure/Auteur
Singh, A.D.
Auteure/Auteur
Suzuki, S.
Auteure/Auteur
Contributrices/contributeurs
Finger, P.T.
Coupland, S.E.
Albert, D.M.
Amiryan, A.G.
Saakyan, S.
Auw-Hädrich, C.
Baker, D.
Barnhill, R.
Caminal, J.M.
Caroll, W.L.
Cassoux, N.
Desjardins, L.G.
Pierron, G.
Catalá-Mora, J.
Chantada, G.
Chévez-Barrios, P.
Max Conway, R.
Damato, B.E.
Demirci, H.
Dutton, J.J.
Esmaeli, B.
Prieto, V.G.
Williams, M.
Gallie, B.L.
Graue, G.F.
Grossniklaus, H.E.
Heegaard, S.
Holbach, L.M.
Honavar, S.G.
Jager, M.J.
Kivelä, T.T.
Kujala, E.
Rouic, L.L.
Mallipatna, A.C.
Modorati, G.M.
Munier, F.L.
Murray, T.G.
Pavlick, A.C.
Pe'er, J.
Pelayes, D.E.
Rodrigues, M.
Sauerwein, WAG
Semenova, E.
Seregard, S.
Shields, C.
Rand Simpson, E.
Singh, A.D.
Suzuki, S.
Washington, M.K.
White, V.A.
Wilson, M.W.
Wittekind, C.W.
Yin, V.
Groupes de travail
AJCC Ophthalmic Oncology Task Force
Liens vers les personnes
Liens vers les unités
ISSN
1468-2079
Statut éditorial
Publié
Date de publication
2022-04
Volume
106
Numéro
4
Première page
510
Dernière page/numéro d’article
517
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
To analyse ocular and systemic findings of patients presenting with systemic metastasis.
It is an international, multicentre, internet-enabled, registry-based retrospective data analysis. Patients were diagnosed between 2001 and 2011. Data included: primary tumour dimensions, extrascleral extension, ciliary body involvement, American Joint Committee on Cancer (AJCC)-tumour, node, metastasis staging, characteristics of metastases.
Of 3610 patients with uveal melanoma, 69 (1.9%; 95% CI 1.5 to 2.4) presented with clinical metastasis (stage IV). These melanomas originated in the iris, ciliary body and choroid in 4%, 16% and 80% of eyes, respectively. Using eighth edition AJCC, 8 (11%), 20 (29%), 24 (35%), and 17 (25%) belonged to AJCC T-categories T1-T4. Risk of synchronous metastases increased from 0.7% (T1) to 1.5% (T2), 2.6% (T3) and 7.9% (T4). Regional lymph node metastases (N1a) were detected in 9 (13%) patients of whom 6 (67%) had extrascleral extension. Stage of systemic metastases (known for 40 (59%) stage IV patients) revealed 14 (35%), 25 (63%) and 1 (2%) had small (M1a), medium-sized (M1b) and large-sized (M1c) metastases, respectively. Location of metastases in stage IV patients were liver (91%), lung (16%), bone (9%), brain (6%), subcutaneous tissue (4%) and others (5%). Multiple sites of metastases were noted in 24%. Compared with the 98.1% of patients who did not present with metastases, those with synchronous metastases had larger intraocular tumours, more frequent extrascleral extension, ciliary body involvement and thus a higher AJCC T-category.
Though higher AJCC T-stage was associated with risk for metastases at diagnosis, even small T1 tumours were stage IV at initial presentation. The liver was the most common site of metastases; however, frequent multiorgan involvement supports initial whole-body staging.
It is an international, multicentre, internet-enabled, registry-based retrospective data analysis. Patients were diagnosed between 2001 and 2011. Data included: primary tumour dimensions, extrascleral extension, ciliary body involvement, American Joint Committee on Cancer (AJCC)-tumour, node, metastasis staging, characteristics of metastases.
Of 3610 patients with uveal melanoma, 69 (1.9%; 95% CI 1.5 to 2.4) presented with clinical metastasis (stage IV). These melanomas originated in the iris, ciliary body and choroid in 4%, 16% and 80% of eyes, respectively. Using eighth edition AJCC, 8 (11%), 20 (29%), 24 (35%), and 17 (25%) belonged to AJCC T-categories T1-T4. Risk of synchronous metastases increased from 0.7% (T1) to 1.5% (T2), 2.6% (T3) and 7.9% (T4). Regional lymph node metastases (N1a) were detected in 9 (13%) patients of whom 6 (67%) had extrascleral extension. Stage of systemic metastases (known for 40 (59%) stage IV patients) revealed 14 (35%), 25 (63%) and 1 (2%) had small (M1a), medium-sized (M1b) and large-sized (M1c) metastases, respectively. Location of metastases in stage IV patients were liver (91%), lung (16%), bone (9%), brain (6%), subcutaneous tissue (4%) and others (5%). Multiple sites of metastases were noted in 24%. Compared with the 98.1% of patients who did not present with metastases, those with synchronous metastases had larger intraocular tumours, more frequent extrascleral extension, ciliary body involvement and thus a higher AJCC T-category.
Though higher AJCC T-stage was associated with risk for metastases at diagnosis, even small T1 tumours were stage IV at initial presentation. The liver was the most common site of metastases; however, frequent multiorgan involvement supports initial whole-body staging.
PID Serval
serval:BIB_7CC43C04C3D4
PMID
Open Access
Oui
Date de création
2023-11-13T08:56:02.685Z
Date de création dans IRIS
2025-05-21T04:36:41Z
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