Titre
Two mouse lines selected for differential sensitivities to beta-carboline-induced seizures are also differentially sensitive to various pharmacological effects of other GABA(A) receptor ligands
Type
article
Institution
Externe
Périodique
Auteur(s)
Rinaldi, Daisy
Auteure/Auteur
Boutrel, Benjamin
Auteure/Auteur
Adrien, Joëlle
Auteure/Auteur
Venault, Patrice
Auteure/Auteur
Chapouthier, Georges
Auteure/Auteur
Liens vers les personnes
ISSN
0001-8244
Statut éditorial
Publié
Date de publication
2000
Volume
30
Numéro
6
Première page
497
Peer-reviewed
Oui
Langue
anglais
Notes
SAPHIRID:67392
Résumé
Two mouse lines were selectively bred according to their sensitivity (BS line) or resistance (BR line) to seizures induced by a single i.p. injection of methyl beta-carboline-3-carboxylate (beta-CCM), an inverse agonist of the GABA(A) receptor benzodiazepine site. Our aim was to characterize both lines' sensitivities to various physiological effects of other ligands of the GABA(A) receptor. We measured diazepam-induced anxiolysis with the elevated plus-maze test, diazepam-induced sedation by recording the vigilance states, and picrotoxin- and pentylenetetrazol-induced seizures after i.p. injections. Results presented here show that the differential sensitivities of BS and BR lines to beta-CCM can be extended to diazepam, picrotoxin, and pentylenetetrazol, suggesting a genetic selection of a general sensitivity and resistance to several ligands of the GABA(A) receptor.
PID Serval
serval:BIB_FA49D05AD2A9
PMID
Date de création
2008-03-11T13:07:51.067Z
Date de création dans IRIS
2025-05-21T05:16:57Z