Titre
A computer model of human atria with reasonable computation load and realistic anatomical properties
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Blanc, O.
Auteure/Auteur
Virag, N.
Auteure/Auteur
Vesin, J. M.
Auteure/Auteur
Kappenberger, L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0018-9294
Statut éditorial
Publié
Date de publication
2001-11
Volume
48
Numéro
11
Première page
1229
Dernière page/numéro d’article
37
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
Atrial fibrillation is the most frequent arrhythmia, provoking discomfort, heart failure and arterial embolisms. The aim of this work is to develop a simplified anatomical computer model of human atria for the study of atrial arrhythmias and the understanding of electrical propagation mechanisms. With the model we propose, up to 40 s of real-time propagation have been simulated on a single-processor computer. The size and the electrophysiological properties of the simulated atria are within realistic values and information about anatomy has been taken into account in a three-dimensional structure. Besides normal sinus beat, pathological phenomena such as flutter and fibrillation have been induced using a programmed stimulation protocol. One important observation in our model is that atrial arrhythmias are a combination of functional and anatomical reentries and that the geometry plays an important role. This virtual atrium can reproduce electrophysiological observations made in humans but with the advantage of showing in great detail how arrhythmias are initiated and sustained. Such details are difficult or impossible to study in humans. This model will serve us as a tool to evaluate the impact of new therapeutic strategies and to improve them.
Sujets
PID Serval
serval:BIB_DB9C804FEACA
PMID
Date de création
2008-02-15T10:29:37.641Z
Date de création dans IRIS
2025-05-21T07:16:32Z