Titre
Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Zimmerman, P. A.
Auteure/Auteur
Woolley, I.
Auteure/Auteur
Masinde, G. L.
Auteure/Auteur
Miller, S. M.
Auteure/Auteur
McNamara, D. T.
Auteure/Auteur
Hazlett, F.
Auteure/Auteur
Mgone, C. S.
Auteure/Auteur
Alpers, M. P.
Auteure/Auteur
Genton, B.
Auteure/Auteur
Boatin, B. A.
Auteure/Auteur
Kazura, J. W.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0027-8424
Statut éditorial
Publié
Date de publication
1999-11
Volume
96
Numéro
24
Première page
13973
Dernière page/numéro d’article
7
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov 23
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov 23
Résumé
In Papua New Guinea (PNG), numerous blood group polymorphisms and hemoglobinopathies characterize the human population. Human genetic polymorphisms of this nature are common in malarious regions, and all four human malaria parasites are holoendemic below 1500 meters in PNG. At this elevation, a prominent condition characterizing Melanesians is alpha(+)-thalassemia. Interestingly, recent epidemiological surveys have demonstrated that alpha(+)-thalassemia is associated with increased susceptibility to uncomplicated malaria among young children. It is further proposed that alpha(+)-thalassemia may facilitate so-called "benign" Plasmodium vivax infection to act later in life as a "natural vaccine" against severe Plasmodium falciparum malaria. Here, in a P. vivax-endemic region of PNG where the resident Abelam-speaking population is characterized by a frequency of alpha(+)-thalassemia >/=0.98, we have discovered the mutation responsible for erythrocyte Duffy antigen-negativity (Fy[a-b-]) on the FY*A allele. In this study population there were 23 heterozygous and no homozygous individuals bearing this new allele (allele frequency, 23/1062 = 0.022). Flow cytometric analysis illustrated a 2-fold difference in erythroid-specific Fy-antigen expression between heterozygous (FY*A/FY*A(null)) and homozygous (FY*A/FY*A) individuals, suggesting a gene-dosage effect. In further comparisons, we observed a higher prevalence of P. vivax infection in FY*A/FY*A (83/508 = 0.163) compared with FY*A/FY*A(null) (2/23 = 0.087) individuals (odds ratio = 2.05, 95% confidence interval = 0.47-8.91). Emergence of FY*A(null) in this population suggests that P. vivax is involved in selection of this erythroid polymorphism. This mutation would ultimately compromise alpha(+)-thalassemia/P. vivax-mediated protection against severe P. falciparum malaria.
Sujets
PID Serval
serval:BIB_A2541037AB49
PMID
Open Access
Oui
Date de création
2008-01-28T10:48:53.283Z
Date de création dans IRIS
2025-05-21T01:17:03Z