Titre
Early appearance of bactericidal antibodies after polysaccharide challenge of toddlers primed with a group C meningococcal conjugate vaccine: what is its role in the maintenance of protection?
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Tsai, T. F.
Auteure/Auteur
Borrow, R.
Auteure/Auteur
Gnehm, H. E.
Auteure/Auteur
Vaudaux, B.
Auteure/Auteur
Heininger, U.
Auteure/Auteur
Desgrandchamps, D.
Auteure/Auteur
Aebi, C.
Auteure/Auteur
Balmer, P.
Auteure/Auteur
Pedersen, R. D.
Auteure/Auteur
Fritzell, B.
Auteure/Auteur
Siegrist, C. A.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1556-6811
Statut éditorial
Publié
Date de publication
2006-08
Volume
13
Numéro
8
Première page
854
Dernière page/numéro d’article
61
Notes
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
The contribution of memory responses after meningococcal vaccination to protection may depend on the rapidity of the response. Toddlers were challenged with a licensed polysaccharide (PS) vaccine 1 year after vaccination with a single dose of meningococcal group C-CRM(197) conjugate (MCC) vaccine at the age of 12 to 15 months. Bactericidal antibodies and immunoglobulin G (IgG) antibodies detected by an enzyme-linked immunosorbent assay (ELISA) were measured before challenge and 4, 7, 14, or 21 Days later ("Days" refer to treatment groups, "days" to sampling days). Among 281 subjects in the intent-to-treat population, 173 per-protocol (PP) subjects were challenged with 10 microg PS antigen and 103 others with a 50-microg PS vaccinating dose. Capsular PS-specific ELISA IgG titers were negligible in baseline samples and increased only twofold within 4 days of PS administration. In contrast, the proportion of PP subjects with serum bactericidal antibody (SBA) titers of >or=1:8 or >or=1:128 increased, respectively, from 41% and 16% before challenge to 84% and 74% at Day 4 and to 100% and 97% at Day 7. Recipients of 50 microg PS responded with similar kinetics but showed a trend toward higher antibody levels. Unexpectedly, 69% of subjects bled on days 2 to 3 already had achieved SBA titers of >or=1:8. The majority of toddlers previously immunized with MCC and challenged 1 year later with PS antigen mounted protective levels of bactericidal antibody within 2 to 4 days.
Sujets
PID Serval
serval:BIB_4886A673CCAB
PMID
Open Access
Oui
Date de création
2008-01-25T09:33:16.661Z
Date de création dans IRIS
2025-05-20T14:36:24Z