Titre

Corticotropin releasing factor activity of CRF 41 in normal man is potentiated by angiotensin II and vasopressin but not by desmopressin

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Gaillard, R. C.
Auteure/Auteur
Riondel, A. M.
Auteure/Auteur
Ling, N.
Auteure/Auteur
Muller, A. F.
Auteure/Auteur
Liens vers les personnes
rgaillar
Liens vers les unités
ISSN
0024-3205
Statut éditorial
Publié
Date de publication
1988
Volume
43
Numéro
23
Première page
1935
Dernière page/numéro d’article
44
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Résumé
Multiple hypothalamic factors seem to influence ACTH release. In vitro and/or in vivo animal models have shown that angiotensin II, vasopressin and some of its analogs are ACTH secretagogues capable of potentiating the corticotropin releasing activity of CRF41. Since these effects are controversial in man, we investigated in 3 groups of volunteers the corticotropin releasing activity of a 2h-infusion of angiotensin II (7 ng/kg/min), vasopressin (1 ng/kg/min) and desmopressin (1 ng/kg/min) given alone or in combination with a bolus injection of 100 micrograms CRF41 by measuring plasma concentrations of ACTH, cortisol, dehydroepiandrosterone and delta 4-androstenedione. Given alone angiotensin II and desmopressin had no significant effect in contrast to vasopressin which increased significantly the ACTH and steroid levels. Angiotensin II and vasopressin were both able to potentiate the corticotropin releasing activity of CRF41, whereas desmopressin was unable to produce such a potentiation. These results suggest that in man vasopressin and angiotensin II may well regulate the responsiveness of the pituitary-adrenal axis in various physiological or pathophysiological situations.
Sujets

Adrenocorticotropic H...

PID Serval
serval:BIB_42D7CADA81D6
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Date de création
2008-02-15T15:58:03.036Z
Date de création dans IRIS
2025-05-20T16:02:14Z