Titre
Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Eliassen, A.H.
Auteure/Auteur
Hendrickson, S.J.
Auteure/Auteur
Brinton, L.A.
Auteure/Auteur
Buring, J.E.
Auteure/Auteur
Campos, H.
Auteure/Auteur
Dai, Q.
Auteure/Auteur
Dorgan, J.F.
Auteure/Auteur
Franke, A.A.
Auteure/Auteur
Gao, Y.T.
Auteure/Auteur
Goodman, M.T.
Auteure/Auteur
Hallmans, G.
Auteure/Auteur
Helzlsouer, K.J.
Auteure/Auteur
Hoffman-Bolton, J.
Auteure/Auteur
Hultén, K.
Auteure/Auteur
Sesso, H.D.
Auteure/Auteur
Sowell, A.L.
Auteure/Auteur
Tamimi, R.M.
Auteure/Auteur
Toniolo, P.
Auteure/Auteur
Wilkens, L.R.
Auteure/Auteur
Winkvist, A.
Auteure/Auteur
Zeleniuch-Jacquotte, A.
Auteure/Auteur
Zheng, W.
Auteure/Auteur
Hankinson, S.E.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1460-2105
Statut éditorial
Publié
Date de publication
2012
Volume
104
Numéro
24
Première page
1905
Dernière page/numéro d’article
1916
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Background Carotenoids, micronutrients in fruits and vegetables, may reduce breast cancer risk. Most, but not all, past studies of circulating carotenoids and breast cancer have found an inverse association with at least one carotenoid, although the specific carotenoid has varied across studies. Methods We conducted a pooled analysis of eight cohort studies comprising more than 80% of the world's published prospective data on plasma or serum carotenoids and breast cancer, including 3055 case subjects and 3956 matched control subjects. To account for laboratory differences and examine population differences across studies, we recalibrated participant carotenoid levels to a common standard by reassaying 20 plasma or serum samples from each cohort together at the same laboratory. Using conditional logistic regression, adjusting for several breast cancer risk factors, we calculated relative risks (RRs) and 95% confidence intervals (CIs) using quintiles defined among the control subjects from all studies. All P values are two-sided. Results Statistically significant inverse associations with breast cancer were observed for α-carotene (top vs bottom quintile RR = 0.87, 95% CI = 0.71 to 1.05, Ptrend = .04), β-carotene (RR = 0.83, 95% CI = 0.70 to 0.98, Ptrend = .02), lutein+zeaxanthin (RR = 0.84, 95% CI = 0.70 to 1.01, Ptrend = .05), lycopene (RR = 0.78, 95% CI = 0.62 to 0.99, Ptrend = .02), and total carotenoids (RR = 0.81, 95% CI = 0.68 to 0.96, Ptrend = .01). β-Cryptoxanthin was not statistically significantly associated with risk. Tests for heterogeneity across studies were not statistically significant. For several carotenoids, associations appeared stronger for estrogen receptor negative (ER(-)) than for ER(+) tumors (eg, β-carotene: ER(-): top vs bottom quintile RR = 0.52, 95% CI = 0.36 to 0.77, Ptrend = .001; ER(+): RR = 0.83, 95% CI = 0.66 to 1.04, Ptrend = .06; Pheterogeneity = .01). Conclusions This comprehensive prospective analysis suggests women with higher circulating levels of α-carotene, β-carotene, lutein+zeaxanthin, lycopene, and total carotenoids may be at reduced risk of breast cancer.
PID Serval
serval:BIB_A97101C838A2
PMID
Open Access
Oui
Date de création
2012-12-27T13:14:07.661Z
Date de création dans IRIS
2025-05-20T22:11:11Z
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Nom
BIB_A97101C838A2.P001.pdf
Version du manuscrit
preprint
Taille
1.52 MB
Format
Adobe PDF
PID Serval
serval:BIB_A97101C838A2.P001
Somme de contrôle
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