Titre
Analyzing Femorotibial Cartilage Thickness Using Anatomically Standardized Maps: Reproducibility and Reference Data.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Favre, J.
Auteure/Auteur
Babel, H.
Auteure/Auteur
Cavinato, A.
Auteure/Auteur
Blazek, K.
Auteure/Auteur
Jolles, B.M.
Co-dernière auteure/Co-dernier auteur
Andriacchi, T.P.
Co-dernière auteure/Co-dernier auteur
Liens vers les personnes
Liens vers les unités
ISSN
2077-0383
Statut éditorial
Publié
Date de publication
2021-01-26
Volume
10
Numéro
3
Première page
461
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Alterations in cartilage thickness (CTh) are a hallmark of knee osteoarthritis, which remain difficult to characterize at high resolution, even with modern magnetic resonance imaging (MRI), due to a paucity of standardization tools. This study aimed to assess a computational anatomy method producing standardized two-dimensional femorotibial CTh maps. The method was assessed with twenty knees, processed following three common experimental scenarios. Cartilage thickness maps were obtained for the femorotibial cartilages by reconstructing bone and cartilage mesh models in tree-dimension, calculating three-dimensional CTh maps, and anatomically standardizing the maps. The intra-operator accuracy (median (interquartile range, IQR) of -0.006 (0.045) mm), precision (0.152 (0.070) mm), entropy (7.02 (0.71) and agreement (0.975 (0.020))) results suggested that the method is adequate to capture the spatial variations in CTh and compare knees at varying osteoarthritis stages. The lower inter-operator precision (0.496 (0.132) mm) and agreement (0.808 (0.108)) indicate a possible loss of sensitivity to detect differences in a setting with multiple operators. The results confirmed the promising potential of anatomically standardized maps, with the lower inter-operator reproducibility stressing the need to coordinate operators. This study also provided essential reference data and indications for future research using CTh maps.
PID Serval
serval:BIB_80203A1DA9FB
PMID
Open Access
Oui
Date de création
2021-02-08T12:14:41.260Z
Date de création dans IRIS
2025-05-21T00:38:48Z
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Nom
33530358_BIB_80203A1DA9FB.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.25 MB
Format
Adobe PDF
PID Serval
serval:BIB_80203A1DA9FB.P001
URN
urn:nbn:ch:serval-BIB_80203A1DA9FB5
Somme de contrôle
(MD5):caf8bf8b7efa37cf8620b9e202836fc7