Titre
Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Leishman, A.J.
Auteure/Auteur
Gapin, L.
Auteure/Auteur
Capone, M.
Auteure/Auteur
Palmer, E.
Auteure/Auteur
MacDonald, H.R.
Auteure/Auteur
Kronenberg, M.
Auteure/Auteur
Cheroutre, H.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1074-7613
Statut éditorial
Publié
Date de publication
2002
Volume
16
Numéro
3
Première page
355
Dernière page/numéro d’article
364
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
The origin and specificity of alphabeta TCR(+) T cells that express CD8alphaalpha have been controversial issues. Here we provide direct evidence that precursors of functional CD8alphaalpha T cells are positively selected in the thymus in the presence of agonist self-peptides. Like conventional positive selection, this agonist selection process requires functional TCR alpha-CPM, whereas it is independent of CD8beta expression. Furthermore, CD8alphaalpha expression on mature, agonist-selected T cells does not imply selection by MHC class I, and CD8alphaalpha(+) T cells can be either class I or class II restricted. Our data define a distinct agonist-dependent, positive selection process in the thymus, and they suggest a function for CD8alphaalpha distinct from the conventional TCR coreceptor function of CD8alphabeta or CD4.
PID Serval
serval:BIB_7C976D1ADD13
PMID
Open Access
Oui
Date de création
2010-02-11T08:54:58.737Z
Date de création dans IRIS
2025-05-21T01:05:36Z