Titre
Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Vezzani, A.
Auteure/Auteur
Dingledine, R.
Auteure/Auteur
Rossetti, A.O.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1473-7175; 1744-8360
Statut éditorial
Publié
Date de publication
2015
Volume
15
Numéro
9
Première page
1081
Dernière page/numéro d’article
1092
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublishDocument Type: Review
Résumé
Status epilepticus (SE) is a life-threatening neurological emergency often refractory to available treatment options. It is a very heterogeneous condition in terms of clinical presentation and causes, which besides genetic, vascular and other structural causes also include CNS or severe systemic infections, sudden withdrawal from benzodiazepines or anticonvulsants and rare autoimmune etiologies. Treatment of SE is essentially based on expert opinions and antiepileptic drug treatment per se seems to have no major impact on prognosis. There is, therefore, urgent need of novel therapies that rely upon a better understanding of the basic mechanisms underlying this clinical condition. Accumulating evidence in animal models highlights that inflammation ensuing in the brain during SE may play a determinant role in ongoing seizures and their long-term detrimental consequences, independent of an infection or auto-immune cause; this evidence encourages reconsideration of the treatment flow in SE patients.
PID Serval
serval:BIB_66CFA0303946
PMID
Date de création
2015-08-28T11:54:51.650Z
Date de création dans IRIS
2025-05-21T03:35:32Z
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Nom
BIB_66CFA0303946.P001.pdf
Version du manuscrit
preprint
Taille
781.1 KB
Format
Adobe PDF
PID Serval
serval:BIB_66CFA0303946.P001
URN
urn:nbn:ch:serval-BIB_66CFA03039466
Somme de contrôle
(MD5):5c8fddb1e6e76333729568c2450ce3f3