Titre
Differential phosphorylation of some proteins of the neuronal cytoskeleton during brain development.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Histochemical Journal
Auteur(s)
Riederer, B.M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0018-2214
Statut éditorial
Publié
Date de publication
1992
Volume
24
Numéro
11
Première page
783
Dernière page/numéro d’article
790
Langue
anglais
Résumé
The cytoskeleton is important for neuronal morphogenesis. During the postnatal development of cat brain, the molecular composition of the neuronal cytoskeleton changes with maturation. Several of its proteins change in their rate of expression, in their degree of phosphorylation, in their subcellular distribution, or in their biochemical properties. It is proposed that phosphorylation is an essential mechanism to regulate the plasticity of the early, juvenile-type cytoskeleton. Among such proteins are several microtubule-associated proteins (MAPs), such as MAP5a, MAP2c or the juvenile tau proteins. Phosphorylation may also act on neurofilaments, postulated to be involved in the adult-type stabilization of axons. These observations imply that phosphorylation may affect cytoskeleton function in axons and dendrites at various developmental stages. Yet, the mechanisms of phosphorylation and its regulation cascades are largely unknown. In view of the topic of this issue on CD15, the potential role of matrix molecules being involved in the modulation of phosphorylation activity and of cytoskeletal properties is addressed.
Sujets
PID Serval
serval:BIB_3DEBA4756023
PMID
Date de création
2008-01-24T13:34:45.057Z
Date de création dans IRIS
2025-05-20T14:57:20Z