Titre
Pharmacogenomics of the OATP and OAT families.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Marzolini, C.
Auteure/Auteur
Tirona, R.G.
Auteure/Auteur
Kim, R.B.
Auteure/Auteur
Liens vers les personnes
ISSN
1462-2416
Statut éditorial
Publié
Date de publication
2004-04
Volume
5
Numéro
3
Première page
273
Dernière page/numéro d’article
282
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Drug disposition is highly dependent on the interplay between drug metabolism and transport in organs such as the intestine, kidney, and liver. Genetically determined variation in drug transporter function or expression is now increasingly recognized to have a significant role as a determinant of intersubject variability in drug response. Similar to the discoveries of functional genetic variations in drug efflux transporters, such as multi-drug resistance proteins 1 and 2, there have been considerable advances in the identification of single nucleotide polymorphisms in transporters that facilitate cellular drug uptake. Among the uptake transporters, members of the organic anion-transporting polypeptides and organic anion transporters can mediate the cellular uptake of a large number of structurally divergent compounds. Accordingly, functionally relevant polymorphisms in these transporters may contribute to interindividual and interethnic variability in drug disposition and response. In this review, recent progress relating to pharmacogenomics of organic anion transporters will be outlined along with a compilation of currently known genetic polymorphisms.
PID Serval
serval:BIB_56B4D87BEB7A
PMID
Date de création
2023-08-25T04:17:25.336Z
Date de création dans IRIS
2025-05-20T18:58:09Z