Titre
A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.
Type
article
Institution
Externe
Périodique
Auteur(s)
Stamenkovic, I.
Auteure/Auteur
Clark, E.A.
Auteure/Auteur
Seed, B.
Auteure/Auteur
Liens vers les personnes
ISSN
0261-4189[print], 0261-4189[linking]
Statut éditorial
Publié
Date de publication
1989
Volume
8
Numéro
5
Première page
1403
Dernière page/numéro d’article
1410
Langue
anglais
Notes
Publication types: Journal Article
Résumé
B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B-cell maturation and epithelial neoplasia. In this work the sequence of a cDNA clone encoding Bp50 was analyzed by a newly derived transition matrix method. Among several interesting relationships with known receptors was found an extensive homology with the nerve growth factor receptor. The mRNA is induced by gamma-interferon in both B cells and epithelial neoplasms, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation.
Sujets
PID Serval
serval:BIB_47029E9855BE
PMID
Date de création
2010-08-25T13:58:49.900Z
Date de création dans IRIS
2025-05-20T19:53:20Z