Titre
Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Nguyen, L. T.
Auteure/Auteur
Elford, A. R.
Auteure/Auteur
Murakami, K.
Auteure/Auteur
Garza, K. M.
Auteure/Auteur
Schoenberger, S. P.
Auteure/Auteur
Odermatt, B.
Auteure/Auteur
Speiser, D. E.
Auteure/Auteur
Ohashi, P. S.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0022-1007
Statut éditorial
Publié
Date de publication
2002-02
Volume
195
Numéro
4
Première page
423
Dernière page/numéro d’article
35
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb 18
Research Support, Non-U.S. Gov't --- Old month value: Feb 18
Résumé
Using a tumor model of spontaneously arising insulinomas expressing a defined tumor-associated antigen, we investigated whether tumor growth promotes cross-presentation and tolerance of tumor-specific T cells. We found that an advanced tumor burden enhanced cross-presentation of tumor-associated antigens to high avidity tumor-specific T cells, inducing T cell proliferation and limited effector function in vivo. However, contrary to other models, tumor-specific T cells were not tolerized despite a high tumor burden. In fact, in tumor-bearing mice, persistence and responsiveness of adoptively transferred tumor-specific T cells were enhanced. Accordingly, a potent T cell-mediated antitumor response could be elicited by intravenous administration of tumor-derived peptide and agonistic anti-CD40 antibody or viral immunization and reimmunization. Thus, in this model, tumor growth promotes activation of high avidity tumor-specific T cells instead of tolerance. Therefore, the host remains responsive to T cell immunotherapy.
Sujets
PID Serval
serval:BIB_061A829BB9D3
PMID
Open Access
Oui
Date de création
2008-01-28T10:33:05.911Z
Date de création dans IRIS
2025-05-20T17:39:53Z
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Nom
BIB_061A829BB9D3.P001.pdf
Version du manuscrit
preprint
Taille
266.29 KB
Format
Adobe PDF
PID Serval
serval:BIB_061A829BB9D3.P001
URN
urn:nbn:ch:serval-BIB_061A829BB9D33
Somme de contrôle
(MD5):d1e78c61a77491afcdae792d02508926