Titre
Conformable neural interface based on off-stoichiometry thiol-ene-epoxy thermosets.
Type
article
Institution
Externe
Périodique
Auteur(s)
Borda, E.
Auteure/Auteur
Medagoda, D.I.
Auteure/Auteur
Airaghi Leccardi, MJI
Auteure/Auteur
Zollinger, E.G.
Auteure/Auteur
Ghezzi, D.
Auteure/Auteur
Liens vers les personnes
ISSN
1878-5905
Statut éditorial
Publié
Date de publication
2023-02
Volume
293
Première page
121979
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Off-stoichiometry thiol-ene-epoxy (OSTE+) thermosets show low permeability to gases and little absorption of dissolved molecules, allow direct low-temperature dry bonding without surface treatments, have a low Young's modulus, and can be manufactured via UV polymerisation. For these reasons, OSTE+ thermosets have recently gained attention for the rapid prototyping of microfluidic chips. Moreover, their compatibility with standard clean-room processes and outstanding mechanical properties make OSTE+ an excellent candidate as a novel material for neural implants. Here we exploit OSTE+ to manufacture a conformable multilayer micro-electrocorticography array with 16 platinum electrodes coated with platinum black. The mechanical properties allow conformability to curved surfaces such as the brain. The low permeability and strong adhesion between layers improve the stability of the device. Acute experiments in mice show the multimodal capacity of the array to record and stimulate the neural tissue by smoothly conforming to the mouse cortex. Devices are not cytotoxic, and immunohistochemistry stainings reveal only modest foreign body reaction after two and six weeks of chronic implantation. This work introduces OSTE+ as a promising material for implantable neural interfaces.
PID Serval
serval:BIB_3D425E4156B7
PMID
Open Access
Oui
Date de création
2024-03-21T12:02:30.715Z
Date de création dans IRIS
2025-05-20T18:24:20Z